Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 3/20 | 0.45 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.45 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | PTK2 | Q05397 | 3/20 | 0.35 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.33 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.33 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.33 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.33 |
| ▸ | NSD2 | O96028 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22862868 | 0.75 | KEAP1 (0.48) | SLC9A1KEAP1NOTUMSLC6A4GRM4 | |
| SCHEMBL282111 | 0.75 | SLC9A1 (0.48) | SLC9A1KEAP1NOTUMSLC6A4GRM4 | |
| SCHEMBL29975783 | 0.75 | SLC9A1 (0.48) | SLC9A1KEAP1NOTUMSLC6A4GRM4 | |
| SCHEMBL9524640 | 0.74 | SLC9A1 (0.38) | SLC9A1KEAP1NOTUMSLC6A4GRM4 | |
| SCHEMBL9868401 | 0.73 | NOTUM (0.38) | SLC9A1KEAP1NOTUMSLC6A4NSD2 | |
| SCHEMBL12560105 | 0.73 | SLC9A1 (0.50) | SLC9A1KEAP1NOTUMSLC6A4GRM4 | |
| SCHEMBL27661677 | 0.72 | KEAP1 (0.46) | SLC9A1KEAP1NOTUMSLC6A4GRM4 | |
| SCHEMBL1161111 | 0.71 | KEAP1 (0.48) | SLC9A1KEAP1NOTUMSLC6A4GRM4 | |
| SCHEMBL8445272 | 0.71 | SLC9A1 (0.48) | SLC9A1KEAP1NOTUMSLC6A4GRM4 | |
| SCHEMBL29490311 | 0.71 | SLC9A1 (0.48) | SLC9A1KEAP1NOTUMSLC6A4GRM4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5039677-A | Estrogen inhibitor | JANSSEN PHARMACEUTICA N.V. (CA) | 1991-08-13 | — | — | US | disclosed |
| US-4943574-A | AROMATASE INHIBITORS, ESTROGEN DISORDERS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-07-24 | — | — | US | disclosed |