Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.41 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.41 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.41 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.40 |
| ▸ | NPC1 | O15118 | 5/20 | 0.40 |
| ▸ | RAB9A | P51151 | 5/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.40 |
| ▸ | RELA | Q04206 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | CASP3 | P42574 | 1/20 | 0.37 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9866914 | 0.86 | SMN1; SMN2 (0.43) | LMNAGAAADORA3SMN1; SMN2NPC1 | |
| SCHEMBL9866312 | 0.85 | SMN1; SMN2 (0.40) | LMNAADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL9867817 | 0.84 | ADORA3 (0.44) | LMNAGAAADORA3SMN1; SMN2RAB9A | |
| SCHEMBL9867104 | 0.84 | LMNA (0.40) | LMNAGAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL9866500 | 0.83 | NPC1 (0.39) | LMNAGAASMN1; SMN2NPC1RAB9A | |
| SCHEMBL9867935 | 0.83 | CYP19A1 (0.44) | ADORA3ADORA2AADORA2BADORA1SMN1; SMN2 | |
| SCHEMBL9867538 | 0.77 | SMN1; SMN2 (0.45) | LMNAADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL7695561 | 0.74 | ADORA3 (0.52) | LMNAADORA3ADORA2AADORA2BADORA1 | |
| SCHEMBL9867476 | 0.73 | MEN1 (0.49) | LMNAGAAADORA3ADORA2AADORA2B | |
| SCHEMBL9867483 | 0.73 | MEN1 (0.49) | LMNAGAAADORA3ADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4873239-A | GLAUCOMA TREATMENT | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-10-10 | — | — | US | claimed |
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | disclosed |
| US-4873239-A | GLAUCOMA TREATMENT | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-10-10 | — | — | US | disclosed |
| US-4758578-A | Arylthiadiazolylsulfonamides, pharmaceutical compositions and use | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-07-19 | — | — | US | disclosed |