SCHEMBL9867935

SCHEMBL9867935

COc1cccc(-c2nsc(S(=O)(=O)N=CN(C)C)n2)c1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP19A1 P11511 2/20 0.44
CLK4 Q9HAZ1 2/20 0.41
DYRK1A Q13627 1/20 0.41
NR1H2 P55055 2/20 0.40
NR1H3 Q13133 2/20 0.40
CYP1A2 P05177 2/20 0.40
CYP3A4 P08684 2/20 0.40
CYP2C9 P11712 2/20 0.40
MAPK1 P28482 2/20 0.40
HSD17B10 Q99714 2/20 0.40
USP2 O75604 1/20 0.40
CYP2D6 P10635 1/20 0.40
ALOX15 P16050 1/20 0.40
CYP2C19 P33261 1/20 0.40
CA2 P00918 2/20 0.39
CA9 Q16790 2/20 0.39
CA12 O43570 1/20 0.39
CA1 P00915 1/20 0.39
NPC1 O15118 2/20 0.39
RAB9A P51151 2/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9867817 0.86 ADORA3 (0.44) CLK4CYP1A2CYP2C9HSD17B10ALOX15
SCHEMBL9867775 0.83 LMNA (0.41) NPC1RAB9ASMN1; SMN2MAPTALDH1A1
SCHEMBL9867042 0.78 CYP19A1 (0.54) CYP19A1CLK4DYRK1ANR1H2NR1H3
SCHEMBL9866914 0.76 SMN1; SMN2 (0.43) HSD17B10NPC1RAB9AHPGDSMN1; SMN2
SCHEMBL9867152 0.75 CYP19A1 (0.42) CYP19A1CLK4DYRK1ANR1H2NR1H3
SCHEMBL9867147 0.75 CYP19A1 (0.42) CYP19A1CLK4DYRK1ANR1H2NR1H3
SCHEMBL9867104 0.74 LMNA (0.40) CLK4CYP1A2CYP3A4MAPK1CYP2D6
SCHEMBL9866500 0.73 NPC1 (0.39) CA2CA9CA12CA1NPC1
SCHEMBL24217120 0.70 CYP19A1 (0.57) CYP19A1CLK4DYRK1ANR1H2NR1H3
SCHEMBL30423929 0.70 CYP19A1 (0.57) CYP19A1CLK4DYRK1ANR1H2NR1H3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4873239-A GLAUCOMA TREATMENT HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1989-10-10 US claimed
US-4985450-A TREATMENT OF GLAUCOMA AVENTIS PHARMACEUTICALS INC. 1991-01-15 US disclosed
US-4873239-A GLAUCOMA TREATMENT HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1989-10-10 US disclosed
US-4758578-A Arylthiadiazolylsulfonamides, pharmaceutical compositions and use HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) 1988-07-19 US disclosed