Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.54 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.53 |
| ▸ | HPGD | P15428 | 4/20 | 0.53 |
| ▸ | RAB9A | P51151 | 3/20 | 0.53 |
| ▸ | TP53 | P04637 | 2/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.40 |
| ▸ | FAAH | O00519 | 1/20 | 0.40 |
| ▸ | ATP4A | P20648 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24217517 | 0.82 | ALDH1A1 (0.61) | ALDH1A1LMNAMAPTHSD17B10HPGD | |
| SCHEMBL9867185 | 0.81 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTATP4AATP4B | |
| SCHEMBL9867758 | 0.81 | CYP19A1 (0.52) | LMNAMAPTHSD17B10RAB9ATP53 | |
| SCHEMBL9877197 | 0.80 | ALDH1A1 (0.45) | ALDH1A1LMNAMAPTHSD17B10HPGD | |
| SCHEMBL9867210 | 0.80 | ADORA3 (0.58) | ALDH1A1LMNARAB9ATP53SMN1; SMN2 | |
| SCHEMBL12266901 | 0.78 | RAB9A (0.53) | ALDH1A1LMNAMAPTHSD17B10HPGD | |
| SCHEMBL23042515 | 0.76 | RAB9A (0.50) | ALDH1A1LMNAMAPTHSD17B10HPGD | |
| SCHEMBL14755837 | 0.76 | ALDH1A1 (0.51) | ALDH1A1LMNAMAPTHSD17B10HPGD | |
| SCHEMBL9869306 | 0.74 | RAB9A (0.49) | ALDH1A1LMNAMAPTHSD17B10HPGD | |
| SCHEMBL3766697 | 0.71 | RAB9A (0.73) | HPGDRAB9ATP53SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985450-A | TREATMENT OF GLAUCOMA | AVENTIS PHARMACEUTICALS INC. | 1991-01-15 | — | — | US | disclosed |
| US-4873239-A | GLAUCOMA TREATMENT | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1989-10-10 | — | — | US | disclosed |
| EP-0276822-A1 | Arylthiadiazolylsulfonamides and derivatives, a process for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1988-08-03 | — | — | EP | disclosed |
| US-4758578-A | Arylthiadiazolylsulfonamides, pharmaceutical compositions and use | HOECHST ROUSSEL PHARMACEUTICALS, INC. (US) | 1988-07-19 | — | — | US | disclosed |