SCHEMBL9868650

SCHEMBL9868650

O=C(O)c1cnc2cnccc2c1Cl

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4C Q9H3R0 8/20 0.43
KDM4A O75164 2/20 0.43
KDM6B O15054 2/20 0.43
KDM4D Q6B0I6 2/20 0.43
KDM4E B2RXH2 1/20 0.43
MEN1 O00255 1/20 0.43
ALDH1A1 P00352 1/20 0.43
MAPT P10636 1/20 0.43
THRB P10828 1/20 0.43
KMT2A Q03164 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
L3MBTL1 Q9Y468 1/20 0.43
KDM5B Q9UGL1 2/20 0.40
KDM4B O94953 1/20 0.40
KDM5C P41229 1/20 0.40
KDM3A Q9Y4C1 1/20 0.40
LMNA P02545 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
CSNK2A2 P19784 3/20 0.39
CSNK2B P67870 3/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9873291 0.83 KMT2A (0.45) KDM4CKDM4DMEN1ALDH1A1MAPT
SCHEMBL15737730 0.80 DHODH (0.45) KDM4CKDM4AKDM6BKDM4DKDM4E
SCHEMBL797828 0.79 MAOA (0.48) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL11880145 0.79 CSF1R (0.54) DHODH
SCHEMBL10998986 0.78 KMT2A (0.54) KDM4EMEN1ALDH1A1MAPTKMT2A
Hydrochloric Acid SCHEMBL7347258 0.78 MAOA (0.47) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL8415023 0.77 KDM4C (0.52) KDM4CKDM4AKDM6BKDM4DKDM4E
SCHEMBL2721434 0.77 LMNA (0.58) KDM4EMEN1ALDH1A1MAPTKMT2A
SCHEMBL1178728 0.77 ALDH1A1 (0.49) KDM4EALDH1A1LMNASMN1; SMN2DHODH
Ethane SCHEMBL5505921 0.77 ALDH1A1 (0.46) KDM4EMEN1ALDH1A1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4996213-A For treating nervous system disorders SANOFI (FR) 1991-02-26 US disclosed