Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | MMP8 | P22894 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | ALKBH1 | Q13686 | 1/20 | 0.42 |
| ▸ | GSR | P00390 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | IGLV6-57 | P01721 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2792023 | 0.91 | LMNA (0.50) | LMNAPOLBGSRIGLV6-57 | |
| SCHEMBL8678282 | 0.84 | LMNA (0.45) | LMNAKMT2APOLBMEN1HSD17B10 | |
| SCHEMBL28008235 | 0.83 | LMNA (0.41) | LMNAKMT2APOLBMEN1HSD17B10 | |
| SCHEMBL27558998 | 0.83 | LMNA (0.43) | LMNAKMT2AMEN1ALDH1A1IGLV6-57 | |
| SCHEMBL648756 | 0.82 | LMNA (0.47) | LMNAKMT2APOLBMEN1HSD17B10 | |
| SCHEMBL6665775 | 0.82 | LMNA (0.47) | LMNAKMT2APOLBMEN1HSD17B10 | |
| SCHEMBL983637 | 0.82 | LMNA (0.47) | LMNAKMT2APOLBMEN1HSD17B10 | |
| SCHEMBL27780529 | 0.81 | LMNA (0.45) | LMNAKMT2APOLBMEN1MMP8 | |
| SCHEMBL28008233 | 0.81 | L3MBTL1 (0.41) | LMNAKMT2APOLBMEN1HSD17B10 | |
| SCHEMBL9608808 | 0.80 | PABPC1 (0.55) | LMNAKMT2APOLBMEN1HSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4981773-A | Method for stabilization of organic base substances against light | FUJI PHOTO FILM CO., LTD. (JP) | 1991-01-01 | — | — | US | disclosed |
| US-4904574-A | INCLUDING METAL COMPLEX | FUJI PHOTO FILM CO., LTD. (JP) | 1990-02-27 | — | — | US | disclosed |
| US-4761181-A | STABILIZING DYES WITH A DITHIOLATO METAL COMPLEX | FUJI PHOTO FILM CO., LTD. (JP) | 1988-08-02 | — | — | US | disclosed |