Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 3/20 | 0.64 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.64 |
| ▸ | GABRA5 | P31644 | 3/20 | 0.64 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.64 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.64 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.64 |
| ▸ | GABRA6 | Q16445 | 2/20 | 0.64 |
| ▸ | GABRP | O00591 | 1/20 | 0.64 |
| ▸ | GABRD | O14764 | 1/20 | 0.64 |
| ▸ | GABRB1 | P18505 | 1/20 | 0.64 |
| ▸ | GRM5 | P41594 | 1/20 | 0.64 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.64 |
| ▸ | GABRA4 | P48169 | 1/20 | 0.64 |
| ▸ | GABRE | P78334 | 1/20 | 0.64 |
| ▸ | GABRG1 | Q8N1C3 | 1/20 | 0.64 |
| ▸ | GABRG3 | Q99928 | 1/20 | 0.64 |
| ▸ | GABRQ | Q9UN88 | 1/20 | 0.64 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10962588 | 0.87 | GABRG2 (0.67) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9869062 | 0.86 | GABRA1 (0.48) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9870366 | 0.85 | GABRA1 (0.47) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9669340 | 0.85 | GABRG2 (0.64) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9669339 | 0.83 | GABRG2 (0.62) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9669559 | 0.83 | GABRG2 (0.62) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10571474 | 0.83 | GABRG2 (0.74) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10568770 | 0.82 | GABRG2 (0.77) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9669365 | 0.82 | GABRG2 (0.80) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL4046321 | 0.82 | GABRG2 (0.73) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5021411-A | Tranquilizers, anticonvulsants | HOFFMANN-LA ROCHE INC. (US) | 1991-06-04 | — | — | US | disclosed |
| US-4863920-A | SEDATIVES, TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1989-09-05 | — | — | US | disclosed |