Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.62 |
| ▸ | PSMD14 | O00487 | 2/20 | 0.37 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.36 |
| ▸ | HPGD | P15428 | 2/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | MPO | P05164 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3086534 | 0.74 | L3MBTL1 (0.69) | L3MBTL1PSMD14MAP2K1ALOX15HTT | |
| SCHEMBL11373363 | 0.72 | L3MBTL1 (0.68) | L3MBTL1ALDH1A1KDM4ETDP1PKM | |
| SCHEMBL9870843 | 0.71 | L3MBTL1 (0.47) | L3MBTL1MAP2K1ALOX15HTTALDH1A1 | |
| SCHEMBL31407999 | 0.70 | L3MBTL1 (0.64) | L3MBTL1PSMD14MAP2K1ALOX15HTT | |
| SCHEMBL69177 | 0.70 | L3MBTL1 (0.64) | L3MBTL1MAP2K1ALOX15HTTALDH1A1 | |
| Hydrochloric Acid SCHEMBL31407932 | 0.69 | L3MBTL1 (0.62) | L3MBTL1PSMD14MAP2K1ALOX15HTT | |
| Hydrochloric Acid SCHEMBL31408057 | 0.69 | L3MBTL1 (0.62) | L3MBTL1PSMD14MAP2K1ALOX15HTT | |
| SCHEMBL13058362 | 0.69 | L3MBTL1 (0.64) | L3MBTL1ALDH1A1KDM4EHPGDHSD17B10 | |
| SCHEMBL31098508 | 0.69 | L3MBTL1 (0.54) | L3MBTL1MAP2K1ALOX15HTTALDH1A1 | |
| SCHEMBL69990 | 0.69 | L3MBTL1 (0.62) | L3MBTL1MAP2K1ALOX15HTTALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006532-A | Enzyme inhibitor; antiinflammatory agents | MERCK & CO. INC., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4904672-A | Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4767766-A | Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1988-08-30 | — | — | US | disclosed |