Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL312146 | 0.76 | L3MBTL1 (0.60) | L3MBTL1MAP2K1KDM4EKMT2AALDH1A1 | |
| SCHEMBL3653582 | 0.75 | L3MBTL1 (0.58) | L3MBTL1MAP2K1KDM4EKMT2AGRM5 | |
| Hydrochloric Acid SCHEMBL11097642 | 0.75 | L3MBTL1 (0.58) | L3MBTL1MAP2K1KDM4EKMT2AALDH1A1 | |
| SCHEMBL7833009 | 0.74 | L3MBTL1 (0.51) | L3MBTL1MAP2K1KDM4ELMNAKMT2A | |
| SCHEMBL2450038 | 0.73 | L3MBTL1 (0.53) | L3MBTL1MAP2K1KDM4EKMT2AGRM5 | |
| SCHEMBL3602782 | 0.72 | L3MBTL1 (0.55) | L3MBTL1KDM4EKMT2AGRM5ALDH1A1 | |
| SCHEMBL9869654 | 0.71 | L3MBTL1 (0.62) | L3MBTL1MAP2K1KDM4EKMT2AALDH1A1 | |
| SCHEMBL28269519 | 0.71 | L3MBTL1 (0.54) | L3MBTL1MAP2K1KDM4EKMT2AGRM5 | |
| SCHEMBL7083185 | 0.71 | L3MBTL1 (0.54) | L3MBTL1MAP2K1KDM4ELMNAKMT2A | |
| SCHEMBL17028439 | 0.70 | L3MBTL1 (0.53) | L3MBTL1MAP2K1KDM4ELMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006532-A | Enzyme inhibitor; antiinflammatory agents | MERCK & CO. INC., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4904672-A | Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4767766-A | Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1988-08-30 | — | — | US | disclosed |