Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | ACHE | P22303 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | BRD4 | O60885 | 1/20 | 0.30 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869316 | 0.83 | LMNA (0.40) | LMNAACHEKDM4ENCOA3 | |
| SCHEMBL9870815 | 0.79 | LMNA (0.48) | LMNAKDM4ENCOA3 | |
| SCHEMBL23457402 | 0.60 | ACHE (0.76) | LMNACYP2D6CYP2C9CYP2C19ACHE | |
| SCHEMBL14463771 | 0.60 | LMNA (1.00) | LMNACYP2C19ACHENCOA3TSHR | |
| SCHEMBL6200136 | 0.59 | LMNA (0.47) | LMNACYP2C19KDM4ETSHR | |
| SCHEMBL6375181 | 0.59 | BRD4 (0.46) | LMNAACHEKDM4EBRD4CREBBP | |
| SCHEMBL31143605 | 0.58 | LMNA (0.53) | LMNACYP2D6KDM4ETSHR | |
| SCHEMBL6200254 | 0.58 | LMNA (0.57) | LMNACYP2D6KDM4ENCOA3 | |
| SCHEMBL23610043 | 0.58 | LMNA (0.53) | LMNACYP2D6KDM4ETSHR | |
| SCHEMBL17263038 | 0.58 | LMNA (0.53) | LMNACYP2D6KDM4ETSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006532-A | Enzyme inhibitor; antiinflammatory agents | MERCK & CO. INC., INC. (US) | 1991-04-09 | — | — | US | disclosed |
| US-4904672-A | Derivatives of 3-hydroxyazabenzo[b]thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1990-02-27 | — | — | US | disclosed |
| US-4767766-A | Derivatives of 3-hydroxyazabenzo(B)thiophene useful as 5-lipoxygenase inhibitors | MERCK & CO., INC. (US) | 1988-08-30 | — | — | US | disclosed |