Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 7/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 4/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6197331 | 0.91 | MAPT (0.41) | LMNAMAPTHPGDHTTGAA | |
| SCHEMBL6197208 | 0.82 | ACHE (0.49) | LMNAMAPTHPGDHTTGAA | |
| SCHEMBL16348040 | 0.80 | LMNA (0.46) | LMNAMAPTHPGDCYP1A2PTGS1 | |
| SCHEMBL6200254 | 0.75 | LMNA (0.57) | LMNAHPGDSLC6A2SLC6A3ALDH1A1 | |
| SCHEMBL4149747 | 0.74 | LMNA (0.48) | LMNAMAPTHPGDCYP1A2PTGS1 | |
| SCHEMBL10247056 | 0.73 | LMNA (0.47) | LMNAMAPTHPGDCYP1A2PTGS1 | |
| SCHEMBL6195615 | 0.72 | AGTR2 (0.35) | SLC6A3AGTR2 | |
| SCHEMBL27488692 | 0.70 | HTR1A (0.61) | LMNAMAPTHPGDCYP1A2PTGS1 | |
| SCHEMBL1637799 | 0.70 | THRB (0.43) | LMNAMAPTHPGDHTTGAA | |
| SCHEMBL477506 | 0.68 | LMNA (0.63) | LMNAMAPTHPGDCYP1A2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0768302-B1 | Hydroxypyridinones | NOVARTIS AG (CH) | 2005-07-06 | — | — | EP | disclosed |
| US-5688815-A | COMPOUNDS FOR REMOVAL OF EXCESS IRON IN MAMMALS | CIBA GEIGY CORPORATION (US) | 1997-11-18 | — | — | US | disclosed |
| CN-1151399-A | Novel hydroxylpyridinones | CIBA GEIGY AG (CH) | 1997-06-11 | — | — | CN | disclosed |
| EP-0768302-A2 | Hydroxypyridinones | Novartis AG (CH) | 1997-04-16 | — | — | EP | disclosed |