Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.75 |
| ▸ | PKM | P14618 | 2/20 | 0.75 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | FABP4 | P15090 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3075637 | 1.00 | ALDH1A1 (0.75) | ALDH1A1PKMTBXA2RMAPK1LMNA | |
| SCHEMBL2677725 | 0.94 | ALDH1A1 (0.74) | ALDH1A1PKMTBXA2RMAPK1LMNA | |
| SCHEMBL2945763 | 0.88 | ALDH1A1 (0.69) | ALDH1A1PKMKMT2AUSP2SMN1; SMN2 | |
| SCHEMBL29163141 | 0.86 | ALDH1A1 (0.71) | ALDH1A1PKMTBXA2RLMNAMEN1 | |
| SCHEMBL29163131 | 0.84 | ALDH1A1 (0.68) | ALDH1A1PKMLMNAMEN1KMT2A | |
| SCHEMBL3074642 | 0.84 | ALDH1A1 (0.67) | ALDH1A1PKMTBXA2RMAPK1FABP4 | |
| SCHEMBL9871290 | 0.84 | ALDH1A1 (0.75) | ALDH1A1PKMTBXA2RMAPK1LMNA | |
| SCHEMBL600045 | 0.84 | ALDH1A1 (0.75) | ALDH1A1PKMTBXA2RMAPK1LMNA | |
| SCHEMBL7392549 | 0.82 | ALDH1A1 (0.84) | ALDH1A1PKMLMNAMEN1KMT2A | |
| SCHEMBL9149721 | 0.82 | ALDH1A1 (0.84) | ALDH1A1PKMMAPK1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997847-A | Thromboxane A2 antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (DE) | 1991-03-05 | — | — | US | disclosed |
| EP-0304271-A2 | Omega-arylsulphonamidoalkanoic acids for treatment of thromboxane medited diseases | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-22 | — | — | EP | disclosed |