Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.75 |
| ▸ | PKM | P14618 | 2/20 | 0.75 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.59 |
| ▸ | MEN1 | O00255 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.59 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | TBXAS1 | P24557 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | FABP4 | P15090 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869950 | 1.00 | ALDH1A1 (0.75) | ALDH1A1PKMTBXA2RMAPK1LMNA | |
| SCHEMBL2677725 | 0.94 | ALDH1A1 (0.74) | ALDH1A1PKMTBXA2RMAPK1LMNA | |
| SCHEMBL2945763 | 0.88 | ALDH1A1 (0.69) | ALDH1A1PKMKMT2AUSP2SMN1; SMN2 | |
| SCHEMBL29163141 | 0.86 | ALDH1A1 (0.71) | ALDH1A1PKMTBXA2RLMNAMEN1 | |
| SCHEMBL29163131 | 0.84 | ALDH1A1 (0.68) | ALDH1A1PKMLMNAMEN1KMT2A | |
| SCHEMBL3074642 | 0.84 | ALDH1A1 (0.67) | ALDH1A1PKMTBXA2RMAPK1FABP4 | |
| SCHEMBL9871290 | 0.84 | ALDH1A1 (0.75) | ALDH1A1PKMTBXA2RMAPK1LMNA | |
| SCHEMBL600045 | 0.84 | ALDH1A1 (0.75) | ALDH1A1PKMTBXA2RMAPK1LMNA | |
| SCHEMBL7392549 | 0.82 | ALDH1A1 (0.84) | ALDH1A1PKMLMNAMEN1KMT2A | |
| SCHEMBL9149721 | 0.82 | ALDH1A1 (0.84) | ALDH1A1PKMMAPK1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261788-A1 | Inhibition of Bid-Induced Cell-Death Using Small Organic Molecules | THE BURNHAM INSTITUTE | 2010-10-14 | — | — | US | disclosed |
| US-7741521-B2 | 4-phenylsulfanyl-phenylamine derivatives used as BH3 Interacting Domain Death Antagonist (BID), for the treatment of neurodegenerative diseases, liver inflammation, multiple sclerosis, heart disease, ischemic injury and for controlling apoptotic cascade | THE BURNHAM INSTITUTE (US) | 2010-06-22 | — | — | US | disclosed |
| US-20070185196-A1 | Inhibitionof bid-induced cell-death using small organic moleculeus | THE BURNHAM INSTITUTE (US) | 2007-08-09 | — | — | US | disclosed |
| WO-2006004622-A2 | INHIBITION OF BID-INDUCED CELL-DEATH USING SMALL ORGANIC MOLECULES | THE BURNHAM INSTITUTE (US) | 2006-01-12 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070185196-A1 | Inhibitionof bid-induced cell-death using small organic moleculeus | BID, BAD, TMBIM6 | ALDH1A1 4595/4885PKM 2694/4885TBXA2R 4218/4885 |
| US-20100261788-A1 | Inhibition of Bid-Induced Cell-Death Using Small Organic Molecules | BID, BAD, TMBIM6 | ALDH1A1 4719/4885PKM 2034/4885TBXA2R 4044/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.