Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 5/20 | 0.53 |
| ▸ | TRHDE | Q9UKU6 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TRHR | P34981 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.42 |
| ▸ | MBTPS1 | Q14703 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5358340 | 0.87 | MAPT (0.46) | TACR1TRHDEMAPTACEPOLB | |
| SCHEMBL31035995 | 0.83 | TRHDE (0.52) | TACR1TRHDE | |
| SCHEMBL9871633 | 0.81 | CPB2 (0.44) | TRHDEMAPTTRHRCDK5CDK5R1 | |
| SCHEMBL868827 | 0.80 | TRHDE (0.48) | TRHDETRHRPOLBCDK5CDK5R1 | |
| SCHEMBL14864806 | 0.80 | TRHDE (0.48) | TRHDETRHRPOLBCDK5CDK5R1 | |
| SCHEMBL13984143 | 0.80 | TRHDE (0.50) | TRHDETRHRCDK5CDK5R1 | |
| SCHEMBL13197411 | 0.79 | TRHDE (0.49) | TRHDEMEN1KMT2ATRHRCDK5 | |
| SCHEMBL755381 | 0.79 | TRHDE (0.54) | TRHDETRHRACECDK5CDK5R1 | |
| SCHEMBL30621980 | 0.78 | TACR1 (0.80) | TACR1MAPTS1PR1ACEMBTPS1 | |
| SCHEMBL19508750 | 0.78 | KLK5 (0.51) | TRHDEACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5025027-A | For stimulation of the parasympathetic system and treatment of glaucoma; improved duration | REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1991-06-18 | — | — | US | disclosed |
| WO-1990010000-A1 | CYCLIC CARBAMATE ANALOGUES OF (+)-PILOCARPINE | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 1990-09-07 | — | — | WO | disclosed |