Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.37 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.37 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.37 |
| ▸ | IKBKB | O14920 | 1/20 | 0.37 |
| ▸ | CHUK | O15111 | 1/20 | 0.37 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.37 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.37 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.37 |
| ▸ | PAK4 | O96013 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9871387 | 1.00 | MEN1 (0.44) | MEN1KMT2ANPC1POLBALDH1A1 | |
| SCHEMBL9871200 | 0.86 | CHEK1 (0.42) | MEN1KMT2AALDH1A1LMNACHEK1 | |
| SCHEMBL9871811 | 0.80 | HCAR2 (0.43) | MEN1KMT2ANPC1POLBALDH1A1 | |
| SCHEMBL9871808 | 0.80 | HCAR2 (0.43) | MEN1KMT2ANPC1POLBALDH1A1 | |
| SCHEMBL8846070 | 0.79 | CHEK1 (0.42) | MEN1KMT2ANPC1ALDH1A1CHEK1 | |
| SCHEMBL9870737 | 0.78 | CHEK1 (0.40) | MEN1KMT2ANPC1ALDH1A1CHEK1 | |
| SCHEMBL9870731 | 0.78 | CHEK1 (0.40) | MEN1KMT2ANPC1ALDH1A1CHEK1 | |
| SCHEMBL18433892 | 0.76 | CYP17A1 (0.43) | MEN1KMT2AALDH1A1LMNACHEK1 | |
| SCHEMBL9871017 | 0.75 | KMT2A (0.43) | MEN1KMT2AALDH1A1ALOX5CDK8 | |
| SCHEMBL9871013 | 0.75 | KMT2A (0.43) | MEN1KMT2AALDH1A1ALOX5CDK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997837-A | Enzyme inhibitors | WARNER-LAMBERT COMPANY (US) | 1991-03-05 | — | — | US | disclosed |
| US-4906624-A | 6-(((Substituted)pyridin-3-yl)alkyl)-and alkenyl)-tetrahydro-4-hydroxypyran-2-one inhibitors of cholesterol biosynthesis | WARNER-LAMBERT COMPANY (US) | 1990-03-06 | — | — | US | disclosed |