Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.60 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | DPP4 | P27487 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873751 | 0.89 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1NPSR1KMT2A | |
| SCHEMBL9874746 | 0.88 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL9873582 | 0.87 | ALDH1A1 (0.55) | ALDH1A1L3MBTL1NPSR1MEN1KMT2A | |
| SCHEMBL9873543 | 0.86 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1NPSR1 | |
| SCHEMBL9874803 | 0.85 | ALDH1A1 (0.66) | ALDH1A1L3MBTL1HPGDSMN1; SMN2CYP2C19 | |
| SCHEMBL9873982 | 0.84 | ALDH1A1 (0.61) | ALDH1A1L3MBTL1NPSR1SMN1; SMN2LMNA | |
| SCHEMBL9873427 | 0.81 | ALDH1A1 (0.55) | ALDH1A1GAAKMT2A | |
| SCHEMBL4001869 | 0.81 | ALDH1A1 (0.74) | ALDH1A1L3MBTL1NPSR1HPGDSMN1; SMN2 | |
| SCHEMBL4001868 | 0.81 | ALDH1A1 (0.74) | ALDH1A1L3MBTL1NPSR1HPGDSMN1; SMN2 | |
| SCHEMBL13803530 | 0.81 | ALDH1A1 (0.59) | ALDH1A1L3MBTL1NPSR1HPGDSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051444-A | Pyrrolidine derivatives as anti-amnesia agents | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1991-09-24 | — | — | US | disclosed |
| US-4880827-A | Pyrrolidine derivatives having inhibitory action for proline specific endopepidase | SUMITOMO PHARMACEUTICALS COMPANY, LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| EP-0238319-A1 | Pyrrolidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1987-09-23 | — | — | EP | disclosed |