Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.66 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | KDM2B | Q8NHM5 | 1/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.45 |
| ▸ | TLR7 | Q9NYK1 | 2/20 | 0.45 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9873427 | 0.88 | ALDH1A1 (0.55) | ALDH1A1KMT2AGAA | |
| SCHEMBL9871405 | 0.85 | ALDH1A1 (0.60) | ALDH1A1CYP2C19KMT2ASMN1; SMN2LMNA | |
| SCHEMBL9873751 | 0.83 | ALDH1A1 (0.57) | ALDH1A1KMT2AL3MBTL1 | |
| SCHEMBL9874746 | 0.82 | ALDH1A1 (0.56) | ALDH1A1L3MBTL1 | |
| SCHEMBL8190806 | 0.82 | ALDH1A1 (0.58) | ALDH1A1KMT2ALMNAL3MBTL1KDM4E | |
| SCHEMBL15595714 | 0.82 | ALDH1A1 (0.58) | ALDH1A1KMT2ALMNAL3MBTL1KDM4E | |
| SCHEMBL8190808 | 0.82 | ALDH1A1 (0.58) | ALDH1A1KMT2ALMNAL3MBTL1KDM4E | |
| SCHEMBL9873582 | 0.81 | ALDH1A1 (0.55) | ALDH1A1KMT2AL3MBTL1MEN1 | |
| SCHEMBL9873543 | 0.81 | ALDH1A1 (0.57) | ALDH1A1L3MBTL1 | |
| SCHEMBL15596155 | 0.78 | FKBP1A (0.62) | ALDH1A1POLBKMT2ASMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5051444-A | Pyrrolidine derivatives as anti-amnesia agents | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1991-09-24 | — | — | US | disclosed |
| US-4880827-A | Pyrrolidine derivatives having inhibitory action for proline specific endopepidase | SUMITOMO PHARMACEUTICALS COMPANY, LTD. (JP) | 1989-11-14 | — | — | US | disclosed |
| EP-0238319-A1 | Pyrrolidine derivatives | SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) | 1987-09-23 | — | — | EP | disclosed |