Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.43 |
| ▸ | PRNP | P04156 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NR2E3 | Q9Y5X4 | 1/20 | 0.43 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | GABRP | O00591 | 2/20 | 0.39 |
| ▸ | GABRD | O14764 | 2/20 | 0.39 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.39 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.39 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.39 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.39 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.39 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4817993 | 0.85 | GABRP (0.39) | CYP1A2RXFP1PRNPCYP2C9CYP2C19 | |
| SCHEMBL10901788 | 0.84 | GABRP (0.43) | CYP1A2RXFP1PRNPCYP2C9CYP2C19 | |
| SCHEMBL28733526 | 0.81 | GABRP (0.41) | CYP1A2RXFP1PRNPCYP2C9CYP2C19 | |
| SCHEMBL7409160 | 0.81 | GABRP (0.41) | CYP1A2TSHRGABRPGABRDGABRA1 | |
| SCHEMBL31535191 | 0.80 | TSHR (0.38) | CYP1A2RXFP1PRNPCYP2C9CYP2C19 | |
| SCHEMBL28670020 | 0.79 | CSNK2A1 (0.46) | CYP1A2TSHRGABRPGABRDGABRA1 | |
| SCHEMBL7410303 | 0.79 | GABRP (0.37) | CYP1A2RXFP1PRNPCYP2C9CYP2C19 | |
| SCHEMBL1251359 | 0.78 | CYP1A2 (0.44) | CYP1A2RXFP1TSHRGABRPGABRD | |
| SCHEMBL21723600 | 0.78 | GABRP (0.39) | CYP1A2TSHRGABRPGABRDGABRA1 | |
| SCHEMBL598480 | 0.78 | PTGS2 (0.42) | CYP1A2CYP2C9CYP2C19HIF1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008285-A | Antiarthritic agent with low gastric irritability side effect | HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) | 1991-04-16 | — | — | US | disclosed |
| EP-0160258-B1 | (6,11-DIHYDRO-11-OXODIBENZ(BM,E)OXEPINYL)PENTANOLS, A PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-09-27 | — | — | EP | disclosed |
| EP-0159684-B1 | (6,11-DIHYDRO-11-OXODIBENZ(B,E)OXEPINYL)PENTANOIC ACIDS AND DERIVATIVES, A PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1989-09-27 | — | — | EP | disclosed |
| EP-0160258-A2 | (6,11-Dihydro-11-oxodibenz(bm,e)oxepinyl)pentanols, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-11-06 | — | — | EP | disclosed |
| EP-0159684-A2 | (6,11-Dihydro-11-oxodibenz(b,e)oxepinyl)pentanoic acids and derivatives, a process and intermediates for their preparation and their use as medicaments | HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) | 1985-10-30 | — | — | EP | disclosed |