Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | GLA | P06280 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | EGFR | P00533 | 2/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.31 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.31 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.31 |
| ▸ | AKR1B1 | P15121 | 2/20 | 0.31 |
| ▸ | HPGD | P15428 | 2/20 | 0.31 |
| ▸ | CA12 | O43570 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | BCHE | P06276 | 1/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10516399 | 0.75 | PDE3B (0.44) | RPS6KB2KDM4EALDH1A1GLAPDGFRB | |
| SCHEMBL310881 | 0.74 | NPC1 (0.58) | KDM4EALDH1A1GLANPC1RAB9A | |
| SCHEMBL9117555 | 0.69 | MEN1 (0.41) | KDM4EALDH1A1GLANPC1RAB9A | |
| SCHEMBL9672578 | 0.69 | MCL1 (0.50) | KDM4EALDH1A1ALOX15TDP1EGFR | |
| SCHEMBL10402599 | 0.68 | DYRK1A (0.42) | KDM4EALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL9979779 | 0.66 | EGFR (0.42) | RPS6KB2KDM4EALDH1A1GLANPC1 | |
| SCHEMBL10415195 | 0.66 | GRM2 (0.38) | KDM4EALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL10651328 | 0.66 | ALOX5 (0.35) | RPS6KB2ALDH1A1NPC1RAB9AALOX15 | |
| SCHEMBL10473035 | 0.64 | ALOX15 (0.34) | KDM4EALDH1A1RAB9AALOX15TDP1 | |
| SCHEMBL8564561 | 0.64 | ALOX15 (0.34) | ALOX15TDP1TYMS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5037983-A | 6,7-dihydroxyquinoxalines as intermediates to beta-lactam antibiotics | E. R. SQUIBB & SONS, INC. (US) | 1991-08-06 | — | — | US | disclosed |
| US-4904775-A | Heteroaroylhydrazide derivatives of monocyclic beta-lactam antibiotics | E. R. SQUIBB & SONS, INC. (US) | 1990-02-27 | — | — | US | disclosed |
| EP-0342423-A2 | Heteroaroylhydrazide derivatives of monocyclic beta-lactam antibiotics | E.R. SQUIBB & SONS, INC. (US) | 1989-11-23 | — | — | EP | disclosed |
| EP-0303286-A1 | 2-Oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines | E.R. Squibb & Sons, Inc. (US) | 1989-02-15 | — | — | EP | disclosed |
| US-4777252-A | 2-oxo-1-[[(substituted sulfonyl)amino]-carbonyl]azetidines | E. R. SQUIBB & SONS, INC. (US) | 1988-10-11 | — | — | US | disclosed |