Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKR1B1 | P15121 | 3/20 | 0.54 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | GRM5 | P41594 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8320456 | 0.89 | AKR1B1 (0.66) | AKR1B1CHRM5MAPTGRM5P2RX7 | |
| SCHEMBL9535759 | 0.87 | AKR1B1 (0.60) | AKR1B1CHRM5MEN1CYP1A2CYP2C9 | |
| SCHEMBL9385856 | 0.87 | AKR1B1 (0.49) | AKR1B1CHRM5MAPT | |
| SCHEMBL9385583 | 0.87 | AKR1B1 (0.54) | AKR1B1CHRM5MAPT | |
| SCHEMBL9383524 | 0.80 | AKR1B1 (0.45) | AKR1B1CHRM5MAPTLMNATSHR | |
| SCHEMBL9684857 | 0.79 | AKR1B1 (0.79) | AKR1B1CHRM5MEN1CYP1A2CYP2C9 | |
| SCHEMBL11791998 | 0.77 | KMT2A (0.53) | LMNATSHRL3MBTL1MEN1KMT2A | |
| SCHEMBL9872084 | 0.75 | AKR1B1 (0.79) | AKR1B1CHRM5MAPTGRM5 | |
| SCHEMBL9383581 | 0.74 | ALDH1A1 (0.48) | MAPTTSHRL3MBTL1MEN1CYP1A2 | |
| SCHEMBL9870040 | 0.72 | AKR1B1 (0.73) | AKR1B1CHRM5MAPTGRM5P2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0555327-B1 | ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO-[ISOQUINOLINE- 4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PROD (US) | 1999-01-13 | — | — | EP | disclosed |
| EP-0553263-B1 | 1'-AMINOSPIRO-[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]- 1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PROD (US) | 1998-08-05 | — | — | EP | disclosed |
| EP-0519600-B1 | Process and intermediate for making isoquinoline derivatives | AMERICAN HOME PROD (US) | 1997-06-11 | — | — | EP | disclosed |
| EP-0365324-B1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PROD (US) | 1994-05-04 | — | — | EP | disclosed |
| EP-0555327-A1 | ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO-[ISOQUINOLINE- 4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-18 | — | — | EP | disclosed |
| EP-0553263-A1 | 1'-AMINOSPIRO-[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]- 1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS IN VIVO | AMERICAN HOME PRODUCTS CORPORATION (US) | 1993-08-04 | — | — | EP | disclosed |
| EP-0519600-A1 | Process and intermediate for making isoquinoline derivatives | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-12-23 | — | — | EP | disclosed |
| US-5169948-A | Process and intermediates for the preparation of spiro[isoquinoline-4(1H),3-pyrrolidine]1,2,3,5 (2H)-tetrones which are useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-12-08 | — | — | US | disclosed |
| US-5130425-A | Antidiabetic agents spiro azetidine-2,4'(1'H)-isoquinoline! 1',3',4(2'H)-triones | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-07-14 | — | — | US | disclosed |
| WO-1992006974-A1 | ALKYLIDENE ANALOGS OF 1'-AMINOSPIRO[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES USEFUL AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-30 | — | — | WO | disclosed |
| WO-1992006975-A1 | 1'-AMINOSPIRO[ISOQUINOLINE-4(1H),3'-PYRROLIDINE]-1,2',3,5'(2H)-TETRONES AND ANALOGS THEREOF USEFUL AS ALDOSE REDUCTASE INHIBITORS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-30 | — | — | WO | disclosed |
| US-5106978-A | Process and intermediates for the preparation of spiro(isoquinoline-4(1H), 3'-pyrrolidine)-1,2', 3,5'(2H)-tetrones which are useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-21 | — | — | US | disclosed |
| US-5102886-A | 1'-aminospiro[isoquinoline-4(1H),3'-pyrrolidine]-1,2',3,5'(2H)-tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-04-07 | — | — | US | disclosed |
| US-5081241-A | Diabetes | AMERICAN HOME PRODUCTS CORPORATION (US) | 1992-01-14 | — | — | US | disclosed |
| EP-0458549-A1 | N-alkyl-spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-11-27 | — | — | EP | disclosed |
| US-5068332-A | Antidiabetic agents | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-11-26 | — | — | US | disclosed |
| US-5045544-A | Preventing or relieving neuropathy, nephropathy, retinopathy or cataracts in diabetic mammals | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-09-03 | — | — | US | disclosed |
| US-4983613-A | Acetamides; treatment of neuropathy, nephropathy, retinopathy or cataracts in diabetic mammals | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-08 | — | — | US | disclosed |
| US-4927831-A | PREVENTION OF DIABETES MELLITUS ASSOCIATED COMPLICATIONS | AMERICAN HOME PRODUCTS (US) | 1990-05-22 | — | — | US | disclosed |
| EP-0365324-A1 | Spiro-isoquinoline-pyrrolidine tetrones and analogs thereof useful as aldose reductase inhibitors | AMERICAN HOME PRODUCTS CORPORATION (US) | 1990-04-25 | — | — | EP | disclosed |