Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 11/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 9/20 | 0.53 |
| ▸ | OGA | O60502 | 6/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | ACHE | P22303 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9752627 | 0.88 | PDE4B (0.69) | PDE4BPDE4DOGA | |
| SCHEMBL9870296 | 0.83 | PDE4B (0.69) | PDE4BPDE4DACHE | |
| SCHEMBL9752596 | 0.78 | PDE4B (0.39) | PDE4BPDE4D | |
| SCHEMBL9871514 | 0.76 | PDE4B (0.41) | PDE4BPDE4D | |
| SCHEMBL9871078 | 0.75 | PDE4B (0.44) | PDE4BPDE4D | |
| SCHEMBL9752615 | 0.73 | PDE4B (0.47) | PDE4BPDE4D | |
| SCHEMBL9871483 | 0.72 | PDE4B (0.46) | PDE4BPDE4D | |
| SCHEMBL9870727 | 0.71 | LMNA (0.53) | PDE4BPDE4DACHE | |
| SCHEMBL9752708 | 0.71 | PDE4B (0.44) | PDE4BPDE4D | |
| Hydrochloric Acid SCHEMBL9752508 | 0.70 | PDE4B (0.43) | PDE4BPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4985560-A | Pyridazino(4,5-b)indolizines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-15 | — | — | US | claimed |
| US-4985560-A | Pyridazino(4,5-b)indolizines | AMERICAN HOME PRODUCTS CORPORATION (US) | 1991-01-15 | — | — | US | disclosed |