Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXAS1 | P24557 | 12/20 | 0.60 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.49 |
| ▸ | CA1 | P00915 | 1/20 | 0.49 |
| ▸ | CA2 | P00918 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27437585 | 0.85 | TBXAS1 (0.57) | TBXAS1HTTALDH1A1TP53GAA | |
| SCHEMBL9577200 | 0.81 | ALDH1A1 (0.68) | ALDH1A1TP53GAAMEN1KMT2A | |
| SCHEMBL9871358 | 0.79 | TBXAS1 (0.54) | TBXAS1HTTALDH1A1TP53GAA | |
| SCHEMBL9870419 | 0.79 | TBXAS1 (0.54) | TBXAS1HTTALDH1A1TP53GAA | |
| SCHEMBL9872413 | 0.79 | TBXA2R (0.75) | TBXAS1ALDH1A1TP53GAATBXA2R | |
| SCHEMBL9871736 | 0.79 | TBXA2R (0.75) | TBXAS1ALDH1A1TP53GAATBXA2R | |
| SCHEMBL9879916 | 0.79 | TBXA2R (0.75) | TBXAS1ALDH1A1TP53GAATBXA2R | |
| SCHEMBL9870095 | 0.79 | TBXA2R (0.75) | TBXAS1ALDH1A1TP53GAATBXA2R | |
| SCHEMBL9870233 | 0.79 | TBXA2R (0.75) | TBXAS1ALDH1A1TP53GAATBXA2R | |
| SCHEMBL9869922 | 0.79 | TBXA2R (0.75) | TBXAS1ALDH1A1TP53GAATBXA2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4997847-A | Thromboxane A2 antagonists | SMITH KLINE & FRENCH LABORATORIES LIMITED (DE) | 1991-03-05 | — | — | US | disclosed |
| EP-0304271-A2 | Omega-arylsulphonamidoalkanoic acids for treatment of thromboxane medited diseases | SMITH KLINE & FRENCH LABORATORIES LIMITED (GB) | 1989-02-22 | — | — | EP | disclosed |