Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 9/20 | 0.66 |
| ▸ | HTR3E | A5X5Y0 | 5/20 | 0.66 |
| ▸ | HTR3B | O95264 | 5/20 | 0.66 |
| ▸ | HTR3D | Q70Z44 | 5/20 | 0.66 |
| ▸ | HTR3C | Q8WXA8 | 5/20 | 0.66 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.66 |
| ▸ | CHRNA1 | P02708 | 1/20 | 0.66 |
| ▸ | CHRNG | P07510 | 1/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.66 |
| ▸ | HTR1A | P08908 | 1/20 | 0.66 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.66 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.66 |
| ▸ | MAPT | P10636 | 1/20 | 0.66 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.66 |
| ▸ | CHRNB1 | P11230 | 1/20 | 0.66 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.66 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.66 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.66 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.66 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9871036 | 0.95 | HTR3A (0.72) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL18299 | 0.80 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL29930627 | 0.80 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL3953452 | 0.80 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL31061471 | 0.80 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL17766649 | 0.80 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL18297 | 0.80 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL29405651 | 0.80 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL463128 | 0.80 | HTR3A (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C | |
| Tropisetron SCHEMBL7375657 | 0.79 | APEX1 (1.00) | HTR3AHTR3EHTR3BHTR3DHTR3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5017582-A | Analgesics | SANDOZ LTD. (CH) | 1991-05-21 | — | — | US | disclosed |
| US-4910207-A | Antipsychotic agent | NOVARTIS AG (CH) | 1990-03-20 | — | — | US | disclosed |
| US-4803199-A | SEROTONIN ANTAGONIST, ANALGESIC ANTIARRHYTHMIC AGENTS | NOVARTIS AG (CH) | 1989-02-07 | — | — | US | disclosed |