SCHEMBL7706502

SCHEMBL7706502

COc1cc(N)c(Cl)cc1C(=O)n1ccnc1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 1/20 0.55
HTR4 Q13639 7/20 0.46
CYP1A2 P05177 2/20 0.46
CYP2D6 P10635 2/20 0.46
HTR3A P46098 2/20 0.46
CYP3A4 P08684 2/20 0.46
CYP2C9 P11712 1/20 0.46
TSHR P16473 1/20 0.46
SMN1; SMN2 Q16637 1/20 0.46
KCNH2 Q12809 2/20 0.46
HTR3E A5X5Y0 1/20 0.46
SLC22A1 O15245 1/20 0.46
HTR3B O95264 1/20 0.46
ALDH1A1 P00352 1/20 0.46
LMNA P02545 1/20 0.46
MPO P05164 1/20 0.46
ADRA2A P08913 1/20 0.46
DRD2 P14416 1/20 0.46
ADRA2C P18825 1/20 0.46
DRD4 P21917 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9459218 0.82 LRRK2 (0.44) DRD2DRD4DRD3
SCHEMBL6775905 0.80 AHR (0.38) GAAHTR4KCNH2ALDH1A1ACHE
SCHEMBL4286867 0.79 KCNMA1 (0.52) GAACYP1A2CYP3A4CYP2C9TSHR
SCHEMBL6780389 0.78 AHR (0.36) GAAHTR4ACHE
SCHEMBL7290470 0.75 NPC1 (0.49) CYP1A2CYP2D6CYP3A4TSHRALDH1A1
SCHEMBL8335586 0.74 NOS2 (0.42) CYP1A2CYP3A4
SCHEMBL30562815 0.74 PIN1 (0.41) GAATSHRSMN1; SMN2ALDH1A1LMNA
SCHEMBL27431185 0.74 HSD11B1 (0.43) HTR4HTR3ACYP3A4TSHRALDH1A1
SCHEMBL15652199 0.73 MEN1 (0.66) GAAHTR4CYP2D6HTR3ACYP3A4
SCHEMBL7280230 0.73 GAA (0.73) GAAHTR4CYP1A2CYP2D6HTR3A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0880500-B1 ESTERS OF 3-HYDROXY-PIPERIDINEMETHANOL DERIVATIVES JANSSEN PHARMACEUTICA NV (BE) 2002-07-31 EP disclosed
US-6096761-A REACTING A N-SUBSTITUTED 4-METHANOL-3-HYDROXY OR ALKOXY-PIPERIDINE INTERMEDIATE WITH A CARBOXYLIC ACID DERIVATIVES; ADMINISTERING TO AN ANIMAL SUFFERING WITH A CONDITION RELATED TO HAMPERED OR IMPAIRED GASTRIC EMPTYING JANSSEN PHARMACEUTICA N.V. (BE) 2000-08-01 US disclosed
EP-0880500-A1 ESTERS OF 3-HYDROXY-PIPERIDINEMETHANOL DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1998-12-02 EP disclosed
WO-1997030031-A1 ESTERS OF 3-HYDROXY-PIPERIDINEMETHANOL DERIVATIVES JANSSEN PHARMACEUTICA N.V. (BE) 1997-08-21 WO disclosed