Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 4/20 | 0.90 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | CYP2J2 | P51589 | 1/20 | 0.57 |
| ▸ | ACHE | P22303 | 3/20 | 0.54 |
| ▸ | BACE1 | P56817 | 2/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.53 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.53 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6362147 | 0.90 | KCNH2 (0.83) | HRH1KCNH2ACHEKDM4EALDH1A1 | |
| SCHEMBL7442047 | 0.86 | KCNH2 (0.69) | HRH1KCNH2ACHEBACE1KDM4E | |
| SCHEMBL9873080 | 0.85 | HRH1 (0.67) | HRH1KCNH2LMNACYP2J2ACHE | |
| SCHEMBL9787488 | 0.85 | HRH1 (0.78) | HRH1KCNH2LMNACYP2J2GAA | |
| Hydrochloric Acid SCHEMBL8200558 | 0.85 | KCNH2 (0.67) | HRH1KCNH2POLBACHEBACE1 | |
| Hydrochloric Acid SCHEMBL9787478 | 0.84 | HRH1 (0.73) | HRH1KCNH2CYP2J2ACHEBACE1 | |
| Hydrochloric Acid SCHEMBL9787500 | 0.84 | HRH1 (0.76) | HRH1KCNH2LMNACYP2J2GAA | |
| SCHEMBL17031600 | 0.81 | HRH1 (1.00) | HRH1KCNH2CYP2J2 | |
| SCHEMBL7477007 | 0.81 | KCNH2 (0.62) | HRH1KCNH2ACHEBACE1ALDH1A1 | |
| SCHEMBL3240024 | 0.81 | KCNH2 (0.78) | HRH1KCNH2CYP2J2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5057524-A | Asthma, dermatitis | A. H. ROBINS COMPANY INCORPORATED (US) | 1991-10-15 | — | — | US | disclosed |
| US-4950674-A | Arylalkylheterocyclic amines,N-substituted by aryloxyalkyl group in a method for allergy treatment | A. H. ROBINS COMPANY, INCORPORATED (US) | 1990-08-21 | — | — | US | disclosed |
| US-4886794-A | ANTIHISTAMINES, ANTIALLERGENS | A. H. ROBINS COMPANY, INCORPORATED (US) | 1989-12-12 | — | — | US | disclosed |
| EP-0291244-A1 | Cyclic carbamate derivatives | A.H. ROBINS COMPANY, INCORPORATED (a Delaware corporation) (US) | 1988-11-17 | — | — | EP | disclosed |