Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A4 known ✓ | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.42 |
| ▸ | SIGMAR1 known ✓ | Q99720 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 5/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.46 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | GRM5 | P41594 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL548941 | 0.77 | ACHE (0.54) | HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL1916659 | 0.76 | ACHE (0.56) | HTR2AHTR2CHTR2BSIGMAR1 | |
| SCHEMBL14485306 | 0.71 | LMNA (0.81) | LMNAMAPK1RAB9AGRIN1GRIN2B | |
| Bromide SCHEMBL7286166 | 0.71 | MCHR1 (0.51) | LMNAMAPK1SLC6A4SLC6A3HTR2A | |
| SCHEMBL5730065 | 0.70 | LMNA (0.78) | LMNAMAPK1RAB9AGRIN1GRIN2B | |
| Valine SCHEMBL6436086 | 0.69 | TACR1 (0.47) | SIGMAR1 | |
| SCHEMBL5668453 | 0.69 | HTR2A (0.54) | GRIN1GRIN2BSLC6A4SLC6A3HTR2A | |
| Hydrochloric Acid SCHEMBL5666575 | 0.68 | HTR2A (0.53) | GRIN1GRIN2BSLC6A4SLC6A3HTR2A | |
| SCHEMBL3634873 | 0.67 | LMNA (0.56) | LMNAMAPK1RAB9AGRIN1GRIN2B | |
| SCHEMBL3251635 | 0.67 | LMNA (0.56) | LMNAMAPK1RAB9AGRIN1GRIN2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5068325-A | Dopaminergic systems as hypotensives, sedatives, antitussives and/or antiphlogistics | KARL THOMAE GMBH (DE) | 1991-11-26 | — | — | US | disclosed |