SCHEMBL987388

SCHEMBL987388

Nc1ccc(Oc2ccc(N)c(C(=O)c3cc(N)cc(N)c3)c2C(=O)c2cc(N)cc(N)c2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PARP10 Q53GL7 1/20 0.44
ALDH1A1 P00352 6/20 0.41
MEN1 O00255 4/20 0.41
KMT2A Q03164 4/20 0.41
MAPT P10636 3/20 0.41
PDE7A Q13946 2/20 0.40
ICAM1 P05362 1/20 0.39
SELE P16581 1/20 0.39
VCAM1 P19320 1/20 0.39
CYP3A4 P08684 1/20 0.38
TSHR P16473 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
HDAC3 O15379 1/20 0.37
BRAF P15056 1/20 0.37
HDAC4 P56524 1/20 0.37
HDAC1 Q13547 1/20 0.37
HDAC7 Q8WUI4 1/20 0.37
HDAC2 Q92769 1/20 0.37
HDAC10 Q969S8 1/20 0.37
HDAC11 Q96DB2 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9449466 0.85 MAOA (0.46) PARP10MEN1KMT2AMAPTGAA
SCHEMBL988595 0.84 KMT2A (0.54) ALDH1A1MEN1KMT2AMAPTPDE7A
SCHEMBL987723 0.80 PBRM1 (0.42) ALDH1A1MEN1KMT2AMAPTTDP1
SCHEMBL30793031 0.71 ALDH1A1 (0.50) PARP10ALDH1A1MEN1KMT2AMAPT
SCHEMBL28212890 0.70 HPGD (0.48) PARP10MEN1KMT2AMAPTCYP3A4
SCHEMBL17281693 0.70 PARP10 (0.66) PARP10ALDH1A1MEN1KMT2AMAPT
SCHEMBL8667036 0.69 ALDH1A1 (0.54) PARP10ALDH1A1MEN1KMT2AMAPT
SCHEMBL3454410 0.69 MAOA (0.53) PARP10ALDH1A1MEN1KMT2AMAPT
SCHEMBL27147137 0.68 PBRM1 (0.52) PARP10ALDH1A1MEN1KMT2AMAPT
SCHEMBL16341914 0.68 SRD5A2 (0.66) PARP10MEN1KMT2ASMN1; SMN2NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130224653-A1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND METHOD FOR PRODUCING THE SAME PI R&D CO., LTD (JP) 2013-08-29 US claimed
US-20110136061-A1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND PROCESS FOR PRODUCING THE SAME ITATANI HIROSHI 2011-06-09 US claimed
EP-1614704-B1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND METHOD FOR PRODUCING THE SAME PI R & D CO LTD (JP) 2011-01-19 EP claimed
US-20130224653-A1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND METHOD FOR PRODUCING THE SAME PI R&D CO., LTD (JP) 2013-08-29 US disclosed
US-20110136061-A1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND PROCESS FOR PRODUCING THE SAME ITATANI HIROSHI 2011-06-09 US disclosed
EP-1614704-B1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND METHOD FOR PRODUCING THE SAME PI R & D CO LTD (JP) 2011-01-19 EP disclosed
US-20070106056-A1 Crosslinked polyimide, composition comprising the same and method for producing the same PI R&D CO., LTD. (JP) 2007-05-10 US disclosed
EP-1614704-A1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND METHOD FOR PRODUCING THE SAME PI R & D Co. Ltd (JP) 2006-01-11 EP disclosed