SCHEMBL987723

SCHEMBL987723

Nc1cc(N)cc(C(=O)c2c(N)ccc(N)c2C(=O)c2cc(N)cc(N)c2)c1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PBRM1 Q86U86 1/20 0.42
MAPT P10636 5/20 0.39
POLB P06746 3/20 0.39
KMT2A Q03164 3/20 0.39
USP2 O75604 2/20 0.39
MEN1 O00255 2/20 0.39
TDP1 Q9NUW8 2/20 0.39
THRB P10828 1/20 0.39
PKM P14618 1/20 0.39
APEX1 P27695 1/20 0.39
RECQL P46063 1/20 0.39
BLM P54132 1/20 0.39
MCL1 Q07820 1/20 0.39
KDM4E B2RXH2 3/20 0.36
LMNA P02545 3/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 1/20 0.36
SMN1; SMN2 Q16637 1/20 0.36
HSD17B10 Q99714 1/20 0.36
MITF O75030 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8196675 0.82 PBRM1 (0.50) PBRM1MAPTPOLBKMT2AUSP2
SCHEMBL987388 0.80 PARP10 (0.44) MAPTKMT2AUSP2MEN1TDP1
SCHEMBL28212890 0.78 HPGD (0.48) MAPTPOLBKMT2AUSP2MEN1
SCHEMBL27147137 0.76 PBRM1 (0.52) PBRM1MAPTPOLBKMT2AUSP2
SCHEMBL4354499 0.74 PBRM1 (0.73) PBRM1MAPTPOLBKMT2AMEN1
SCHEMBL7456279 0.74 TDP1 (0.46) PBRM1MAPTPOLBKMT2AUSP2
SCHEMBL28135536 0.73 ALDH1A1 (0.62) PBRM1MAPTPOLBKMT2AUSP2
SCHEMBL24587796 0.73 LMNA (0.50) PBRM1MAPTPOLBKMT2ATDP1
SCHEMBL8992948 0.73 PBRM1 (0.77) PBRM1POLBKMT2AMEN1TDP1
SCHEMBL11788105 0.71 PBRM1 (0.68) PBRM1MAPTPOLBTDP1RECQL

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130224653-A1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND METHOD FOR PRODUCING THE SAME PI R&D CO., LTD (JP) 2013-08-29 US claimed
US-20110136061-A1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND PROCESS FOR PRODUCING THE SAME ITATANI HIROSHI 2011-06-09 US claimed
EP-1614704-B1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND METHOD FOR PRODUCING THE SAME PI R & D CO LTD (JP) 2011-01-19 EP claimed
US-20070106056-A1 Crosslinked polyimide, composition comprising the same and method for producing the same PI R&D CO., LTD. (JP) 2007-05-10 US claimed
EP-1614704-A1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND METHOD FOR PRODUCING THE SAME PI R & D Co. Ltd (JP) 2006-01-11 EP claimed
US-20130224653-A1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND METHOD FOR PRODUCING THE SAME PI R&D CO., LTD (JP) 2013-08-29 US disclosed
US-20110136061-A1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND PROCESS FOR PRODUCING THE SAME ITATANI HIROSHI 2011-06-09 US disclosed
EP-1614704-B1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND METHOD FOR PRODUCING THE SAME PI R & D CO LTD (JP) 2011-01-19 EP disclosed
US-20070106056-A1 Crosslinked polyimide, composition comprising the same and method for producing the same PI R&D CO., LTD. (JP) 2007-05-10 US disclosed
EP-1614704-A1 CROSSLINKED POLYIMIDE, COMPOSITION COMPRISING THE SAME AND METHOD FOR PRODUCING THE SAME PI R & D Co. Ltd (JP) 2006-01-11 EP disclosed