Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALM1 | P0DP23 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.50 |
| ▸ | PPARA | Q07869 | 1/20 | 0.49 |
| ▸ | IGF1R | P08069 | 1/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.49 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.46 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.46 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL79113 | 0.88 | CALM1 (0.68) | CALM1ALOX5CYP4A11PPARAIGF1R | |
| SCHEMBL24197389 | 0.82 | MAOB (0.61) | CALM1ALOX5CYP4A11PPARAIGF1R | |
| SCHEMBL1171813 | 0.82 | CALM1 (0.66) | CALM1ALOX5CYP4A11IGF1RALOX15 | |
| SCHEMBL8413383 | 0.80 | CALM1 (0.63) | CALM1ALOX5CYP4A11IGF1RALOX15 | |
| SCHEMBL8862032 | 0.80 | CALM1 (0.63) | CALM1ALOX5CYP4A11IGF1RALOX15 | |
| SCHEMBL4740749 | 0.80 | CALM1 (0.63) | CALM1ALOX5CYP4A11IGF1RALOX15 | |
| SCHEMBL7051536 | 0.79 | KCNJ1 (0.54) | CALM1ALOX5IGF1RALOX15KCNJ1 | |
| SCHEMBL29886710 | 0.78 | LTA4H (0.73) | CALM1MAPTRAB9APOLBLTA4H | |
| Hydrocinnamyl Alcohol SCHEMBL9875250 | 0.77 | TDP1 (0.52) | MAPTRAB9ALTA4HEPHX2 | |
| SCHEMBL8957360 | 0.77 | CALM1 (0.50) | CALM1ALOX5IGF1RALOX15KCNJ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5049694-A | Cardiovascular disorders | CEDONA PHARMACEUTICALS B.V. (NL) | 1991-09-17 | — | — | US | disclosed |
| EP-0359335-A2 | Pharmaceutical composition having relaxing activity which contains a nitrate ester as active substance | CEDONA PHARMACEUTICALS B.V. (NL) | 1990-03-21 | — | — | EP | disclosed |