Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | DPP8 | Q6V1X1 | 3/20 | 0.49 |
| ▸ | DPP7 | Q9UHL4 | 3/20 | 0.49 |
| ▸ | DPP4 | P27487 | 2/20 | 0.49 |
| ▸ | DPP9 | Q86TI2 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | METAP2 | P50579 | 1/20 | 0.48 |
| ▸ | METAP1 | P53582 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.46 |
| ▸ | CTSB | P07858 | 1/20 | 0.46 |
| ▸ | CTSS | P25774 | 1/20 | 0.46 |
| ▸ | CTSK | P43235 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 2/20 | 0.46 |
| ▸ | NFE2L2 | Q16236 | 2/20 | 0.46 |
| ▸ | ANPEP | P15144 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10521370 | 0.87 | METAP2 (0.52) | MEN1KMT2AMETAP2METAP1ALDH1A1 | |
| SCHEMBL10521376 | 0.87 | METAP2 (0.52) | MEN1KMT2AMETAP2METAP1ALDH1A1 | |
| SCHEMBL9770911 | 0.87 | METAP2 (0.52) | MEN1KMT2AMETAP2METAP1ALDH1A1 | |
| Hydroxyamine SCHEMBL7357468 | 0.83 | REN (0.53) | MEN1KMT2AMETAP2METAP1CTSL | |
| SCHEMBL9874408 | 0.83 | REN (0.49) | MEN1KMT2AMETAP2CTSLCTSS | |
| SCHEMBL8392487 | 0.80 | MEN1 (0.62) | MEN1KMT2AHTTALDH1A1KEAP1 | |
| SCHEMBL8395472 | 0.80 | MEN1 (0.62) | MEN1KMT2AHTTALDH1A1KEAP1 | |
| SCHEMBL9876326 | 0.79 | CA1 (0.50) | CTSLCTSSCTSKHTRA1REN | |
| SCHEMBL6476379 | 0.78 | METAP2 (0.64) | MEN1KMT2AMETAP2METAP1ALDH1A1 | |
| SCHEMBL8395610 | 0.78 | HTT (0.62) | MEN1KMT2ADPP8DPP7DPP4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5147857-A | Enzyme inhibitors | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 1992-09-15 | — | — | US | disclosed |
| EP-0446751-A1 | Glycolic acid derivatives | MERCK PATENT GmbH (DE) | 1991-09-18 | — | — | EP | disclosed |
| EP-0339483-A2 | Renin inhbiting amino-acid derivatives | MERCK PATENT GmbH (DE) | 1989-11-02 | — | — | EP | disclosed |