SCHEMBL9874615

SCHEMBL9874615

CC(C)c1nc2cc[c]cc2s1

nearest known ligand 0.39

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
LOXL2 Q9Y4K0 1/20 0.39
CASR P41180 1/20 0.34
ALOX5 P09917 1/20 0.34
RAB9A P51151 3/20 0.33
HPGD P15428 1/20 0.33
NPC1 O15118 1/20 0.33
SCN4A P35499 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
TLR8 Q9NR97 1/20 0.33
TLR7 Q9NYK1 1/20 0.33
MAPK9 P45984 1/20 0.32
MAPK10 P53779 1/20 0.32
MAPT P10636 1/20 0.32
PAX8 Q06710 1/20 0.32
NOD2 Q9HC29 1/20 0.32
L3MBTL1 Q9Y468 1/20 0.32
GAA P10253 1/20 0.31
TSHR P16473 1/20 0.31
MAPK1 P28482 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL693730 0.77 GAA (0.50) RAB9AHPGDNPC1SMN1; SMN2MAPT
SCHEMBL4236785 0.75 TLR8 (0.37) LOXL2RAB9AHPGDNPC1SMN1; SMN2
SCHEMBL3191166 0.75 MEN1 (0.41) RAB9AHPGDSMN1; SMN2
SCHEMBL27359885 0.73 HPGD (0.34) LOXL2HPGDMAPK9MAPK10
SCHEMBL62420 0.73 LOXL2 (0.66) LOXL2CASRALOX5RAB9AHPGD
SCHEMBL145436 0.73 KDM4E (0.30) RAB9AHPGDNPC1SMN1; SMN2MAPT
SCHEMBL25429178 0.72
SCHEMBL1360954 0.72 KMT2A (0.40) RAB9ANPC1SMN1; SMN2MAPTGAA
SCHEMBL406704 0.72 RAB9A (0.47) RAB9AHPGDNPC1SCN4ASMN1; SMN2
SCHEMBL1358985 0.71 LDHA (0.44) RAB9ANPC1SMN1; SMN2MAPTL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5064846-A Heterocyclic insecticides ICI AMERICAS INC. (US) 1991-11-12 US claimed