Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.46 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 3/20 | 0.46 |
| ▸ | TOP2A | P11388 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10744735 | 0.86 | POLB (0.61) | POLBSMN1; SMN2ALDH1A1MAPK1RECQL | |
| SCHEMBL31745160 | 0.86 | POLB (0.61) | POLBSMN1; SMN2ALDH1A1MAPK1RECQL | |
| SCHEMBL31745360 | 0.85 | POLB (0.60) | POLBSMN1; SMN2ALDH1A1MAPK1RECQL | |
| SCHEMBL10743454 | 0.85 | POLB (0.60) | POLBSMN1; SMN2ALDH1A1MAPK1RECQL | |
| SCHEMBL10588005 | 0.78 | LMNA (0.55) | POLBSMN1; SMN2ALDH1A1MAPK1RECQL | |
| SCHEMBL14825070 | 0.77 | POLB (1.00) | POLBSMN1; SMN2ALDH1A1MAPK1RECQL | |
| SCHEMBL9197789 | 0.76 | RECQL (0.81) | SMN1; SMN2ALDH1A1MAPK1RECQLMAPT | |
| SCHEMBL28670364 | 0.75 | PKM (0.54) | SMN1; SMN2PKML3MBTL1LMNATRPM8 | |
| Phenylacetic Acid SCHEMBL28334050 | 0.75 | PAM (0.65) | SMN1; SMN2ALDH1A1MAPK1PKML3MBTL1 | |
| SCHEMBL5010738 | 0.75 | SMN1; SMN2 (1.00) | POLBSMN1; SMN2ALDH1A1RECQLMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1991009019-A1 | SUBSTITUTED OXOPHTHALAZINYL ACETIC ACIDS AND ANALOGS THEREOF | PFIZER INC. (US) | 1991-06-27 | — | — | WO | disclosed |