Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Niacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | GAA | P10253 | 2/20 | 0.63 |
| ▸ | APP | P05067 | 1/20 | 0.63 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.63 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.63 |
| ▸ | F7 | P08709 | 1/20 | 0.61 |
| ▸ | F3 | P13726 | 1/20 | 0.61 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.61 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.61 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.61 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.61 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niacin SCHEMBL30468338 | 1.00 | ALDH1A1 (0.63) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| Niacin SCHEMBL1943861 | 0.96 | ALDH1A1 (0.63) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| Niacin SCHEMBL587526 | 0.96 | ALDH1A1 (0.63) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| Niacin SCHEMBL6012008 | 0.96 | ALDH1A1 (0.63) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| Niacin SCHEMBL25269786 | 0.96 | ALDH1A1 (0.63) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| Niacin SCHEMBL23780930 | 0.96 | ALDH1A1 (0.63) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| Niacin SCHEMBL3498987 | 0.96 | ALDH1A1 (0.63) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| Niacin SCHEMBL10357700 | 0.96 | ALDH1A1 (0.63) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| Niacin SCHEMBL308681 | 0.96 | ALDH1A1 (0.63) | ALDH1A1GAAAPPHCAR3HCAR2 | |
| Niacin SCHEMBL517582 | 0.96 | ALDH1A1 (0.63) | ALDH1A1GAAAPPHCAR3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 95 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12506143-B2 | Electrode plate, electrochemical apparatus, and electronic apparatus | NINGDE AMPEREX TECHNOLOGY LIMITED (CN) | 2025-12-23 | — | — | US | claimed |
| US-20230238519-A1 | ELECTRODE PLATE, ELECTROCHEMICAL APPARATUS, AND ELECTRONIC APPARATUS | NINGDE AMPEREX TECHNOLOGY LIMITED (CN) | 2023-07-27 | — | — | US | claimed |
| EP-0272903-B1 | PROCESS FOR PRODUCING A POLYARYLENE SULFIDE | Tosoh Corporation (JP) | 1993-07-21 | — | — | EP | claimed |
| US-4794163-A | HIGH MOLECULAR WEIGHT, HEAT RESISTANCE | TOSOH CORPORATION (JP) | 1988-12-27 | — | — | US | claimed |
| EP-0272903-A2 | Process for producing a polyarylene sulfide | Tosoh Corporation (JP) | 1988-06-29 | — | — | EP | claimed |
| JP-1249754-A | — | — | None | — | — | JP | disclosed |
| JP-1249754-A | — | — | None | — | — | JP | disclosed |
| US-12506143-B2 | Electrode plate, electrochemical apparatus, and electronic apparatus | NINGDE AMPEREX TECHNOLOGY LIMITED (CN) | 2025-12-23 | — | — | US | disclosed |
| EP-4439911-A1 | ELECTROCHEMICAL DEVICE AND CONTROL METHOD THEREFOR, ELECTRONIC DEVICE, AND STORAGE MEDIUM | Ningde Amperex Technology Limited (CN) | 2024-10-02 | — | — | EP | disclosed |
| US-20240313277-A1 | ELECTROCHEMICAL APPARATUS AND CONTROL METHOD THEREFOR, ELECTRONIC APPARATUS, AND STORAGE MEDIUM | NINGDE AMPEREX TECHNOLOGY LIMITED (CN) | 2024-09-19 | — | — | US | disclosed |
| US-20240304784-A1 | ELECTROCHEMICAL APPARATUS AND ELECTRONIC APPARATUS | NINGDE AMPEREX TECHNOLOGY LIMITED (CN) | 2024-09-12 | — | — | US | disclosed |
| EP-4428938-A1 | ELECTROCHEMICAL APPARATUS AND ELECTRONIC APPARATUS | Ningde Amperex Technology Limited (CN) | 2024-09-11 | — | — | EP | disclosed |
| US-20110009665-A1 | Acetic acid production by way of carbonylation with enhanced reaction and flashing | CELANESE INTERNATIONAL CORPORATION | 2011-01-13 | — | — | US | disclosed |
| WO-2011005304-A2 | ACETIC ACID PRODUCTION BY WAY OF CARBONYLATION WITH ENHANCED REACTION AND FLASHING | CELANESE INTERNATIONAL CORPORATION (US) | 2011-01-13 | — | — | WO | disclosed |
| EP-0272903-B1 | PROCESS FOR PRODUCING A POLYARYLENE SULFIDE | Tosoh Corporation (JP) | 1993-07-21 | — | — | EP | disclosed |
| US-4908374-A | Nicotinic acid lithium salt | ODESSKY MEDITSINSKY INSTITUT IMENI N.I. PIROGOVA, ODESSA, USSR | 1990-03-13 | — | — | US | disclosed |
| JP-H01249754-A | LITHIUM NICOTINATE SALT SEMIHYDRATE AND PHARMACEUTICAL PREPARATION BASED THEREON FOR PREVENTION AND TREATMENT OF ALCOHOLIC INTOXICATION | ODESKY MEDIZIN INST IM NI PIROGOVA | 1989-10-05 | — | — | JP | disclosed |
| JP-H01249754-A | LITHIUM NICOTINATE SALT SEMIHYDRATE AND PHARMACEUTICAL PREPARATION BASED THEREON FOR PREVENTION AND TREATMENT OF ALCOHOLIC INTOXICATION | ODESKY MEDIZIN INST IM NI PIROGOVA | 1989-10-05 | — | — | JP | disclosed |
| US-4794163-A | HIGH MOLECULAR WEIGHT, HEAT RESISTANCE | TOSOH CORPORATION (JP) | 1988-12-27 | — | — | US | disclosed |
| EP-0272903-A2 | Process for producing a polyarylene sulfide | Tosoh Corporation (JP) | 1988-06-29 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110009665-A1 | Acetic acid production by way of carbonylation with enhanced reaction and flashing | DNMT1, SP1, ME1 | ALDH1A1 253/4885GAA 4409/4885APP 4735/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.