Known targets — ChEMBL curated mechanism
GABBR1GABBR2GABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BHMGCRMMP1MMP13MMP7MMP8PTGS1PTGS2ileSpolrplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Niacin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.63 |
| ▸ | APP | P05067 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.63 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.63 |
| ▸ | F7 | P08709 | 1/20 | 0.61 |
| ▸ | F3 | P13726 | 1/20 | 0.61 |
| ▸ | SARM1 | Q6SZW1 | 1/20 | 0.61 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.61 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.61 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.61 |
| ▸ | SIRT5 | Q9NXA8 | 1/20 | 0.61 |
| ▸ | SIRT4 | Q9Y6E7 | 1/20 | 0.61 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.57 |
| ▸ | PLOD2 | O00469 | 2/20 | 0.53 |
| ▸ | LMNA | P02545 | 3/20 | 0.52 |
| ▸ | THRB | P10828 | 1/20 | 0.52 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Niacin SCHEMBL27516641 | 0.98 | ALDH1A1 (0.61) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL308681 | 0.96 | ALDH1A1 (0.63) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL987479 | 0.96 | ALDH1A1 (0.63) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL517582 | 0.96 | ALDH1A1 (0.63) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL25269786 | 0.96 | ALDH1A1 (0.63) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL23780930 | 0.96 | ALDH1A1 (0.63) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL3498987 | 0.96 | ALDH1A1 (0.63) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL1943861 | 0.96 | ALDH1A1 (0.63) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL10357700 | 0.96 | ALDH1A1 (0.63) | ALDH1A1APPGAAHCAR3HCAR2 | |
| Niacin SCHEMBL6012008 | 0.96 | ALDH1A1 (0.63) | ALDH1A1APPGAAHCAR3HCAR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 76 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240075043-A1 | IMMEDIATE AND CONTROLLED RELEASE APPETITE SUPPRESSANT COMPOSITIONS FOR WEIGHT LOSS | Red Mountain Med Spa, LLC (US) | 2024-03-07 | — | — | US | claimed |
| WO-2023091370-A1 | EXCIPIENT COMPOUNDS FOR BIOPOLYMER FORMULATIONS | COMERA LIFE SCIENCES, INC. (US) | 2023-05-25 | — | — | WO | claimed |
| US-20220249505-A1 | APPETITE SUPPRESSANT COMPOSITIONS AND METHODS THEREOF | RED MOUNTAIN HOLDINGS, LLC (US) | 2022-08-11 | — | — | US | claimed |
| CN-113476669-A | Medicine coating composition and coating process thereof | 北京永益润成科技有限公司 | 2021-10-08 | — | — | CN | claimed |
| US-20210275536-A1 | APPETITE SUPPRESSANT COMPOSITIONS AND METHODS THEREOF | RED MOUNTAIN HOLDINGS, LLC (US) | 2021-09-09 | — | — | US | claimed |
| CN-111671982-A | Medicinal coating composition and preparation method thereof | 北京永益润成科技有限公司 | 2020-09-18 | — | — | CN | claimed |
| US-20180161365-A1 | Phosphate-Binding Magnesium Salts And Uses Thereof | CURRAX PHARMACEUTICALS LLC | 2018-06-14 | — | — | US | claimed |
| US-20180078672-A1 | HAEMOSTATIC AND WOUND HEALING MEDICINE | LIMITED LIABILITY COMPANY "TECTUM" (RU) | 2018-03-22 | — | — | US | claimed |
| US-9889157-B2 | Phosphate-binding magnesium salts and uses thereof | CYPRESS PHARMACEUTICALS, INC. (US) | 2018-02-13 | — | — | US | claimed |
| EP-3278815-A1 | HAEMOSTATIC AND WOUND HEALING MEDICINE | Limited Liability Company "Tectum" (RU) | 2018-02-07 | — | — | EP | claimed |
| EP-2416786-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | Cypress Pharmaceutical, Inc. (US) | 2012-02-15 | — | — | EP | claimed |
| US-20110135750-A1 | ANTI-ALLERGEN COMBINATIONS OF CALCIUM AND LANTHANUM | BYLEMANS DANY LEOPOLD JOZEFIEN | 2011-06-09 | — | — | US | claimed |
| EP-2323485-A1 | ANTI-ALLERGEN COMBINATIONS OF CALCIUM AND LANTHANUM SALTS | Janssen Pharmaceutica, N.V. (BE) | 2011-05-25 | — | — | EP | claimed |
| WO-2010117370-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICALS, INC. (US) | 2010-10-14 | — | — | WO | claimed |
| WO-2010015697-A1 | ANTI-ALLERGEN COMBINATIONS OF CALCIUM AND LANTHANUM SALTS | JANSSEN PHARMACEUTICA NV (BE) | 2010-02-11 | — | — | WO | claimed |
| US-20090269399-A1 | PHOSPHATE-BINDING MAGNESIUM SALTS AND USES THEREOF | CYPRESS PHARMACEUTICAL, INC. (US) | 2009-10-29 | — | — | US | claimed |
| US-6830764-B2 | Applying an effective amount of alkaline earth metal salt selected from calcium and strontium salts to place where allergen exists or will exist | SHINTO FINE CO., LTD. (JP) | 2004-12-14 | — | — | US | claimed |
| EP-1133918-B1 | Method for denaturing allergens using calcium or strontium salts | SUMITOMO CHEMICAL CO (JP) | 2004-09-08 | — | — | EP | claimed |
| US-20010048097-A1 | Method for denaturing allergens | SUMIKA ENVIRO-SCIENCE CO., LTD. (JP) | 2001-12-06 | — | — | US | claimed |
| EP-1133918-A1 | Method for denaturing allergens using calcium or strontium salts | Sumitomo Chemical Co.,Ltd. (JP) | 2001-09-19 | — | — | EP | claimed |