Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | SRC | P12931 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PKM | P14618 | 1/20 | 0.42 |
| ▸ | PDE6D | O43924 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE6A | P16499 | 1/20 | 0.42 |
| ▸ | PDE6G | P18545 | 1/20 | 0.42 |
| ▸ | PDE6B | P35913 | 1/20 | 0.42 |
| ▸ | PDE6C | P51160 | 1/20 | 0.42 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9875153 | 0.86 | PDE5A (0.53) | GAAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL9382784 | 0.85 | KDM4E (0.39) | GAAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL9872808 | 0.83 | KMT2A (0.40) | GAAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL9382963 | 0.82 | KMT2A (0.64) | GAAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL9875116 | 0.81 | GAA (0.44) | GAAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL9875344 | 0.80 | ATM (0.52) | GAAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL9874344 | 0.78 | GAA (0.46) | GAAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL21982994 | 0.77 | LMNA (0.61) | GAAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL9382967 | 0.76 | MEN1 (0.49) | GAAMEN1KMT2AKDM4EMAPT | |
| SCHEMBL10607926 | 0.76 | KDM4E (0.72) | GAAMEN1KMT2AKDM4EMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026711-A | Prevention and treatment of cardiovascular disorders and infections states; anxiolytic and anti-allergic agents | SANOFI (FR) | 1991-06-25 | — | — | US | claimed |
| JP-2032058-A | — | — | None | — | — | JP | disclosed |
| JP-H0232058-A | 4-AMINO-3-CABOXYQUINOLINES AND NAPHTHYLIDINES, THEIR PREPARATION AND MEDICAL USE | SANOFI SA | 1990-02-01 | — | — | JP | disclosed |