Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.53 |
| ▸ | PDE6D | O43924 | 1/20 | 0.53 |
| ▸ | PDE6A | P16499 | 1/20 | 0.53 |
| ▸ | PDE6G | P18545 | 1/20 | 0.53 |
| ▸ | PDE6B | P35913 | 1/20 | 0.53 |
| ▸ | PDE6C | P51160 | 1/20 | 0.53 |
| ▸ | PDE6H | Q13956 | 1/20 | 0.53 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9874892 | 0.86 | GAA (0.53) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL10670455 | 0.77 | PDE5A (0.60) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL9872808 | 0.77 | KMT2A (0.40) | PDE5ATHRBGAANPSR1RXFP1 | |
| SCHEMBL7069841 | 0.77 | THRB (0.58) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL14378112 | 0.76 | THRB (0.62) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL9874344 | 0.76 | GAA (0.46) | THRBGAANPSR1RXFP1MEN1 | |
| SCHEMBL9875116 | 0.75 | GAA (0.44) | GAANPSR1RXFP1MEN1KMT2A | |
| SCHEMBL430575 | 0.75 | THRB (0.61) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL429137 | 0.74 | PDE5A (0.60) | PDE5APDE6DPDE6APDE6GPDE6B | |
| SCHEMBL437005 | 0.74 | THRB (0.60) | PDE5APDE6DPDE6APDE6GPDE6B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5026711-A | Prevention and treatment of cardiovascular disorders and infections states; anxiolytic and anti-allergic agents | SANOFI (FR) | 1991-06-25 | — | — | US | disclosed |