Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 6/20 | 0.58 |
| ▸ | CYP2C9 | P11712 | 6/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 6/20 | 0.58 |
| ▸ | ADORA3 | P0DMS8 | 6/20 | 0.58 |
| ▸ | CACNA1C | Q13936 | 5/20 | 0.58 |
| ▸ | TSHR | P16473 | 4/20 | 0.58 |
| ▸ | NFKB1 | P19838 | 4/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.58 |
| ▸ | MEN1 | O00255 | 3/20 | 0.58 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | CACNA1F | O60840 | 3/20 | 0.45 |
| ▸ | CACNA1D | Q01668 | 3/20 | 0.45 |
| ▸ | CACNA1S | Q13698 | 3/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 3/20 | 0.45 |
| ▸ | THPO | P40225 | 2/20 | 0.45 |
| ▸ | ABCC4 | O15439 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11009095 | 0.89 | ADORA3 (0.74) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9875988 | 0.87 | NR1I2 (0.61) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9875432 | 0.86 | MAPT (0.58) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9875437 | 0.86 | MAPT (0.58) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7272013 | 0.86 | MAPT (0.79) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL10516658 | 0.85 | MAPT (0.46) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9875222 | 0.83 | CACNA1C (0.56) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9876069 | 0.83 | CACNA1C (0.55) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9876125 | 0.81 | CACNA1C (0.54) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL9873330 | 0.81 | ADORA3 (0.53) | MAPTCYP1A2CYP3A4CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5008279-A | Circulation-active fluoromethoxyphenyl dihydropyridine compounds | BAYER AKTIENGESELLSCHAFT (DE) | 1991-04-16 | — | — | US | disclosed |