SCHEMBL9875649

SCHEMBL9875649

COc1ccc(CNc2c3c(nc4ccccc24)CCCC3=O)cc1

nearest known ligand 0.63

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
MEN1 O00255 2/20 0.54
KMT2A Q03164 2/20 0.54
KDM4E B2RXH2 1/20 0.54
HTT P42858 1/20 0.54
BCHE P06276 4/20 0.53
ACHE P22303 3/20 0.53
CYP1A2 P05177 2/20 0.53
CYP3A4 P08684 2/20 0.53
EGFR P00533 1/20 0.53
BACE1 P56817 1/20 0.53
APP P05067 3/20 0.52
PDE5A O76074 2/20 0.49
NCF1 P14598 1/20 0.48
ACP1 P24666 1/20 0.47
CYP2D6 P10635 1/20 0.47
CYP2C9 P11712 1/20 0.47
CYP2C19 P33261 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8984077 0.89 KMT2A (0.67) MEN1KMT2AKDM4EHTTBCHE
SCHEMBL9875605 0.89 ACHE (0.55) MEN1KMT2AKDM4EHTTBCHE
SCHEMBL10847628 0.88 PDE5A (0.51) MEN1KMT2AKDM4EHTTBCHE
SCHEMBL9875000 0.88 KDM4E (0.57) MEN1KMT2AKDM4EHTTBCHE
SCHEMBL9876065 0.88 KMT2A (0.55) MEN1KMT2AKDM4EHTTBCHE
SCHEMBL10845035 0.87 ACHE (0.73) MEN1KMT2AKDM4EBCHEACHE
SCHEMBL9873820 0.86 KDM4E (0.57) MEN1KMT2AKDM4EHTTBCHE
SCHEMBL9875822 0.86 KMT2A (0.57) MEN1KMT2AKDM4EHTTBCHE
SCHEMBL9876195 0.83 CYP1A2 (0.51) MEN1KMT2AKDM4EHTTBCHE
SCHEMBL9875622 0.83 KDM4E (0.54) MEN1KMT2AKDM4EHTTBCHE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4695573-A COGNITION ACTIVATORS HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1987-09-22 US claimed
EP-2681554-B1 BLOOD COLLECTION DEVICE CONTAINING LYSOPHOSPHOLIPASE INHIBITOR BECTON DICKINSON CO (US) 2017-08-09 EP disclosed
US-9459187-B2 Blood collection device containing lysophospholipase inhibitor BECTON, DICKINSON AND COMPANY (US) 2016-10-04 US disclosed
CN-104244902-A Sample collection devices with blood stabilizing agents BECTON DICKINSON CO 2014-12-24 CN disclosed
US-20140030754-A1 BLOOD COLLECTION DEVICE CONTAINING LYSOPHOSPHOLIPASE INHIBITOR BECTON, DICKINSON AND COMPANY (US) 2014-01-30 US disclosed
US-20130209985-A1 SAMPLE COLLECTION DEVICES WITH BLOOD STABILIZING AGENTS BECTON, DICKINSON AND COMPANY 2013-08-15 US disclosed
EP-0179383-B1 9-AMINO-1,2,3,4-TETRAHYDROACRIDIN-1-OL AND RELATED COMPOUNDS, A PROCESS FOR THEIR PREPARATION AND THEIR USE AS MEDICAMENTS HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1991-05-29 EP disclosed
US-4839364-A ALZHEIMER*S DISEASE; CHOLINESTERASE INHIBITORS HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1989-06-13 US disclosed
US-4835275-A Method of preparing 9-amino-1,2,3,4,-tetrahydroacridin-1-ones and related compounds HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1989-05-30 US disclosed
US-4754050-A COGNITION ACTIVATORS HOECHST-ROUSSEL PHARMACEUTICALS, INC. (US) 1988-06-28 US disclosed
US-4695573-A COGNITION ACTIVATORS HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1987-09-22 US disclosed
US-4631286-A MEMORY ENHANCERS HOECHST-ROUSSEL PHARMACEUTICALS INC. (US) 1986-12-23 US disclosed
EP-0179383-A2 9-Amino-1,2,3,4-tetrahydroacridin-1-ol and related compounds, a process for their preparation and their use as medicaments HOECHST-ROUSSEL PHARMACEUTICALS INCORPORATED (US) 1986-04-30 EP disclosed