Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 4/20 | 0.40 |
| ▸ | AKT1 | P31749 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 6/20 | 0.33 |
| ▸ | NOS1 | P29475 | 1/20 | 0.33 |
| ▸ | NOS2 | P35228 | 1/20 | 0.33 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.31 |
| ▸ | HTR3B | O95264 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | HTR2C | P28335 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.31 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.31 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | PDE4A | P27815 | 1/20 | 0.30 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.30 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.30 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876975 | 0.81 | NR4A2 (0.44) | TP53AKT1BRD4POLB | |
| SCHEMBL27321364 | 0.68 | NOS2 (0.38) | TP53NOS2PDE4BPOLBRXFP1 | |
| SCHEMBL9876847 | 0.67 | KCNH2 (0.61) | TP53HTR6HTR1AHTR2CHTR3A | |
| SCHEMBL9876607 | 0.67 | NR4A2 (0.44) | TP53BRD4 | |
| SCHEMBL9879885 | 0.66 | NOS2 (0.51) | NOS1NOS2HTR3EHTR3BHTR3A | |
| SCHEMBL9686523 | 0.64 | TP53 (0.40) | TP53HTR6HTR3EHTR3BHTR1A | |
| SCHEMBL9537090 | 0.64 | TP53 (0.44) | TP53POLB | |
| SCHEMBL9876634 | 0.63 | NR4A2 (0.44) | TP53BRD4PDE4BPDE4DPOLB | |
| SCHEMBL9698202 | 0.63 | NR4A2 (0.46) | TP53POLB | |
| SCHEMBL9535843 | 0.63 | KCNH2 (0.54) | TP53POLBRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006527-A | Antihistamines, antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-09 | — | — | US | disclosed |