Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR4A2 | P43354 | 1/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.41 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.37 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.36 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.34 |
| ▸ | FLT3 | P36888 | 1/20 | 0.33 |
| ▸ | AKT1 | P31749 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876607 | 0.86 | NR4A2 (0.44) | NR4A2KCNH2TP53SOS1CYP1A2 | |
| SCHEMBL9876847 | 0.85 | KCNH2 (0.61) | NR4A2KCNH2TP53SOS1CYP1A2 | |
| SCHEMBL27321364 | 0.84 | NOS2 (0.38) | TP53CYP1A2LMNACYP2C19ALDH1A1 | |
| SCHEMBL9698202 | 0.83 | NR4A2 (0.46) | NR4A2KCNH2TP53SOS1LMNA | |
| SCHEMBL9876634 | 0.82 | NR4A2 (0.44) | NR4A2KCNH2TP53SOS1CYP1A2 | |
| SCHEMBL9879885 | 0.82 | NOS2 (0.51) | LMNAHSD17B10ALDH1A1TDP1 | |
| SCHEMBL9876795 | 0.81 | TP53 (0.40) | TP53BRD4POLBAKT1 | |
| Noberastine SCHEMBL18424 | 0.81 | NR4A2 (0.45) | NR4A2KCNH2TP53SOS1CYP1A2 | |
| SCHEMBL5111365 | 0.81 | NR4A2 (0.46) | NR4A2KCNH2TP53SOS1CYP1A2 | |
| Water SCHEMBL9685786 | 0.81 | SLC6A9 (0.41) | KCNH2TP53CYP1A2LMNABRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006527-A | Antihistamines, antiallergens | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-09 | — | — | US | disclosed |
| US-4897401-A | N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives useful in treating allergic diseases | JANSSEN PHARMACEUTICAL N.V. (BE) | 1990-01-30 | — | — | US | disclosed |
| EP-0295742-A1 | Novel N-(4-piperidinyl) bicyclic condensed 2-imidazolamine derivatives | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-12-21 | — | — | EP | disclosed |