Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 3/20 | 0.54 |
| ▸ | GRM5 | P41594 | 2/20 | 0.45 |
| ▸ | ESR1 | P03372 | 7/20 | 0.44 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | PTGER1 | P34995 | 1/20 | 0.39 |
| ▸ | KDM5A | P29375 | 1/20 | 0.39 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.39 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | FEN1 | P39748 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9876686 | 0.78 | PTGER1 (0.50) | ESR1HPGDPTGER1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9876681 | 0.77 | CCNA2 (0.49) | ESR1HPGDPTGER1ALDH1A1SMN1; SMN2 | |
| SCHEMBL10530734 | 0.77 | NAMPT (0.43) | NAMPTGRM5IDH1KDM5AKDM4C | |
| SCHEMBL20551427 | 0.76 | KDM5A (0.44) | NAMPTKDM5AKDM4CKDM5BSMN1; SMN2 | |
| SCHEMBL4025528 | 0.76 | NAMPT (0.50) | NAMPTESR1HPGDALDH1A1SMN1; SMN2 | |
| SCHEMBL15064423 | 0.75 | NAMPT (0.53) | NAMPTESR1HPGDALDH1A1 | |
| SCHEMBL9876766 | 0.75 | PTGER1 (0.53) | ESR1HPGDPTGER1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9876695 | 0.75 | CCNA2 (0.49) | ESR1HPGDPTGER1 | |
| SCHEMBL9876850 | 0.75 | MAPT (0.47) | ESR1HPGDPTGER1ALDH1A1SMN1; SMN2 | |
| SCHEMBL9877081 | 0.75 | CCNA2 (0.49) | ESR1PTGER1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006520-A | Antibiotics, antitumor agents, treatment of blood disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-04-09 | — | — | US | disclosed |
| EP-0338087-A1 | FUSED PYRAZOLE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR MEDICINAL USE | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-10-25 | — | — | EP | disclosed |