SCHEMBL9876887

SCHEMBL9876887

Clc1cc(SCc2ccccc2)ccn1

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HSD17B10 Q99714 1/20 0.50
MAOA P21397 3/20 0.46
MAOB P27338 3/20 0.46
MAPK13 O15264 1/20 0.46
MAPK12 P53778 1/20 0.46
MAPK11 Q15759 1/20 0.46
MAPK14 Q16539 1/20 0.46
SCN9A Q15858 1/20 0.44
CYP3A4 P08684 3/20 0.42
CYP2C9 P11712 3/20 0.42
CYP1A2 P05177 2/20 0.42
CYP2C19 P33261 2/20 0.42
ALDH1A1 P00352 2/20 0.42
MEN1 O00255 1/20 0.42
CYP2D6 P10635 1/20 0.42
ALOX12 P18054 1/20 0.42
KMT2A Q03164 1/20 0.42
TRPA1 O75762 1/20 0.42
MAPK1 P28482 1/20 0.42
RECQL P46063 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28804423 0.86 MAPK1 (0.54) MAOAMAOBCYP3A4CYP2C9CYP1A2
SCHEMBL17397997 0.80 POLB (0.49) HSD17B10MAOAMAOBSCN9ACYP3A4
SCHEMBL29661774 0.80 MAOB (0.52) MAOAMAOBCYP3A4CYP2C9CYP1A2
SCHEMBL190495 0.80 MAOB (0.52) MAOAMAOBCYP3A4CYP2C9CYP1A2
SCHEMBL23585274 0.79 HSD17B10 (0.50) HSD17B10MAOAMAOBSCN9ACYP3A4
SCHEMBL7826032 0.79 SCN9A (0.51) HSD17B10MAOAMAOBSCN9ACYP3A4
SCHEMBL29464854 0.79 RAB9A (0.53) HSD17B10MAOAMAOBSCN9ACYP3A4
SCHEMBL19927726 0.79 RAB9A (0.53) HSD17B10MAOAMAOBSCN9ACYP3A4
SCHEMBL19927769 0.79 MAOA (0.50) HSD17B10MAOAMAOBMAPK13MAPK12
SCHEMBL29464907 0.79 MAOA (0.50) HSD17B10MAOAMAOBMAPK13MAPK12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4987141-A DERIVATIVES OF BENZENE OR PYRIDINE HAVING SULFONATE AND SULFENYL, SULFONIMIDE OR SULFONAMIDE GROUPS IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1991-01-22 US disclosed
CN-1042144-A Pesticidal compound ICI PLC (GB) 1990-05-16 CN disclosed
EP-0356029-A2 Insecticidal compounds IMPERIAL CHEMICAL INDUSTRIES PLC (GB) 1990-02-28 EP disclosed