Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 8/20 | 0.70 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.58 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | MAOA | P21397 | 6/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.52 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.51 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.51 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877037 | 0.90 | MAOB (0.60) | MAOBALOX5MAOAMCL1LTB4R | |
| SCHEMBL7907726 | 0.90 | MAOB (0.72) | MAOBALOX5TSHRMAOAAPP | |
| SCHEMBL567416 | 0.82 | MAOB (1.00) | MAOBMAOA | |
| SCHEMBL29945833 | 0.82 | MAOB (1.00) | MAOBMAOA | |
| SCHEMBL1519064 | 0.82 | MAOB (0.77) | MAOBMAOAAPPMCL1PTGS1 | |
| SCHEMBL7796801 | 0.82 | MAOB (0.77) | MAOBALOX5MAOAAPPMCL1 | |
| SCHEMBL629952 | 0.80 | MAOB (0.74) | MAOBTSHRMAOAAPPMCL1 | |
| SCHEMBL9748049 | 0.80 | MAOB (0.74) | MAOBMAOAAPPMCL1PTGS1 | |
| SCHEMBL9877598 | 0.80 | ALOX5 (0.68) | MAOBALOX5PTGS1PTGS2 | |
| SCHEMBL7907691 | 0.80 | MAOB (0.73) | MAOBMAOAAPPMCL1PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |