Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.68 |
| ▸ | MAOB | P27338 | 1/20 | 0.67 |
| ▸ | NR4A1 | P22736 | 1/20 | 0.66 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.66 |
| ▸ | NR4A3 | Q92570 | 1/20 | 0.66 |
| ▸ | EGFR | P00533 | 4/20 | 0.63 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.62 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.60 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877432 | 0.91 | ALOX5 (0.62) | ALOX5MAOBNR4A1NR4A2NR4A3 | |
| SCHEMBL8200793 | 0.89 | MAOB (0.69) | ALOX5MAOBNR4A1NR4A2NR4A3 | |
| SCHEMBL31326509 | 0.86 | MAOB (0.65) | ALOX5MAOBNR4A1NR4A2NR4A3 | |
| SCHEMBL1034311 | 0.85 | MAOB (0.63) | ALOX5MAOBNR4A1NR4A2NR4A3 | |
| SCHEMBL10412775 | 0.84 | PKM (0.64) | PARP10 | |
| SCHEMBL10466517 | 0.84 | MAOB (0.69) | ALOX5MAOBNR4A1NR4A2NR4A3 | |
| SCHEMBL9508209 | 0.84 | FFAR1 (0.58) | ALOX5 | |
| SCHEMBL6703917 | 0.81 | NR4A2 (0.70) | ALOX5MAOBNR4A1NR4A2NR4A3 | |
| SCHEMBL11877158 | 0.81 | NR4A1 (0.66) | ALOX5MAOBNR4A1NR4A2NR4A3 | |
| SCHEMBL2755055 | 0.81 | ALOX5 (1.00) | ALOX5MAOBPTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |