Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDPK1 | O15530 | 1/20 | 0.49 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.47 |
| ▸ | MAP2K4 | P45985 | 3/20 | 0.47 |
| ▸ | MAPKAPK2 | P49137 | 3/20 | 0.47 |
| ▸ | MAPK6 | Q16659 | 3/20 | 0.47 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.47 |
| ▸ | MAPKAPK3 | Q16644 | 2/20 | 0.47 |
| ▸ | MAPKAPK5 | Q8IW41 | 1/20 | 0.47 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.47 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.47 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.47 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | CDC7 | O00311 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.39 |
| ▸ | IDO1 | P14902 | 2/20 | 0.39 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.39 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.39 |
| ▸ | CDK1 | P06493 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1513056 | 0.84 | ALDH1A1 (0.55) | GAAIDO1LRRK2NPSR1KDM4E | |
| SCHEMBL30931548 | 0.84 | ALDH1A1 (0.55) | GAAIDO1LRRK2NPSR1KDM4E | |
| SCHEMBL25029271 | 0.83 | ALDH1A1 (0.54) | MAPK1MAP2K4CDC7GSK3BALDH1A1 | |
| SCHEMBL2926259 | 0.82 | PIM1 (0.51) | PDPK1MAPK1ROCK1GAAIDO1 | |
| SCHEMBL17922026 | 0.78 | LRRK2 (0.41) | ROCK1GAAIDO1LRRK2KDM4E | |
| SCHEMBL27947482 | 0.76 | IDO1 (0.50) | MAP2K4IDO1LRRK2 | |
| SCHEMBL1573790 | 0.76 | AXL (0.41) | HSP90AB1CDC7IDO1LRRK2GSK3A | |
| SCHEMBL29930484 | 0.75 | DYRK1B (0.56) | PDPK1HSP90AB1MAPK1MAP2K4MAPKAPK2 | |
| SCHEMBL22044852 | 0.74 | ROCK1 (0.62) | ROCK1GAA | |
| SCHEMBL10530840 | 0.74 | CA1 (0.43) | GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5006520-A | Antibiotics, antitumor agents, treatment of blood disorders | YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) | 1991-04-09 | — | — | US | disclosed |
| EP-0338087-A1 | FUSED PYRAZOLE COMPOUNDS, PROCESS FOR THEIR PREPARATION, AND THEIR MEDICINAL USE | Yoshitomi Pharmaceutical Industries, Ltd. (JP) | 1989-10-25 | — | — | EP | disclosed |