Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 0.82 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.59 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.57 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.53 |
| ▸ | KDM4A | O75164 | 1/20 | 0.52 |
| ▸ | KDM5A | P29375 | 1/20 | 0.52 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.52 |
| ▸ | PHF8 | Q9UPP1 | 1/20 | 0.52 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.52 |
| ▸ | MGLL | Q99685 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.49 |
| ▸ | MMP12 | P39900 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10695244 | 0.90 | ALOX5 (1.00) | ALOX5HDAC2HDAC1KDM4AKDM5A | |
| SCHEMBL9877206 | 0.89 | ALOX5 (0.63) | ALOX5HDAC2FFAR1MMP12 | |
| SCHEMBL9662985 | 0.89 | ALOX5 (0.97) | ALOX5HDAC2HDAC1KDM4AKDM5A | |
| SCHEMBL8695755 | 0.82 | ALOX5 (0.63) | ALOX5HDAC2HDAC1FFAR1KDM4A | |
| SCHEMBL11802541 | 0.80 | HDAC2 (0.66) | ALOX5HDAC2HDAC1FFAR1MGLL | |
| SCHEMBL1958621 | 0.80 | FFAR1 (0.75) | HDAC2HDAC1FFAR1MGLLMAPT | |
| SCHEMBL11699696 | 0.79 | NPC1 (0.55) | ALOX5HDAC2HDAC1FFAR1MGLL | |
| SCHEMBL9876864 | 0.79 | HDAC3 (0.67) | ALOX5HDAC2HDAC1 | |
| SCHEMBL8716210 | 0.79 | HDAC2 (0.67) | ALOX5HDAC2HDAC1FFAR1MGLL | |
| SCHEMBL25169928 | 0.78 | MAPT (0.79) | HDAC2HDAC1FFAR1KDM4AKDM5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |