Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 3/20 | 0.63 |
| ▸ | FFAR1 | O14842 | 3/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.56 |
| ▸ | MMP12 | P39900 | 1/20 | 0.56 |
| ▸ | NAAA | Q02083 | 1/20 | 0.50 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL448875 | 0.89 | ALOX5 (0.77) | ALOX5FFAR1KMT2AMEN1 | |
| SCHEMBL9877306 | 0.89 | ALOX5 (0.82) | ALOX5FFAR1MMP12HDAC2 | |
| SCHEMBL7088866 | 0.88 | FFAR1 (0.65) | FFAR1KMT2AMMP12NAAAFFAR4 | |
| SCHEMBL8699095 | 0.80 | MLYCD (0.64) | ALOX5FFAR1KMT2AMMP12MEN1 | |
| SCHEMBL8260837 | 0.78 | ALDH1A1 (0.77) | FFAR1MMP12NAAAFFAR4HDAC2 | |
| SCHEMBL9877244 | 0.78 | SMN1; SMN2 (0.64) | ALOX5FFAR1KMT2AMEN1 | |
| SCHEMBL8618654 | 0.77 | FFAR1 (1.00) | FFAR1MMP12NAAAFFAR4 | |
| SCHEMBL1211561 | 0.77 | FFAR1 (1.00) | FFAR1MMP12NAAAFFAR4 | |
| SCHEMBL10695244 | 0.77 | ALOX5 (1.00) | ALOX5KMT2AHDAC2 | |
| SCHEMBL9877712 | 0.77 | LTA4H (0.60) | ALOX5FFAR1FFAR4HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |