Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER1 | P34995 | 7/20 | 0.56 |
| ▸ | RXRA | P19793 | 1/20 | 0.55 |
| ▸ | RXRB | P28702 | 1/20 | 0.55 |
| ▸ | RXRG | P48443 | 1/20 | 0.55 |
| ▸ | MRGPRX4 | Q96LA9 | 6/20 | 0.53 |
| ▸ | PTGER4 | P35408 | 5/20 | 0.52 |
| ▸ | PTGER3 | P43115 | 5/20 | 0.52 |
| ▸ | PTGER2 | P43116 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.51 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.51 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MITF | O75030 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9707333 | 0.81 | MRGPRX4 (0.70) | MRGPRX4SMN1; SMN2L3MBTL1NPC1HPGD | |
| SCHEMBL13739157 | 0.78 | RXRA (0.59) | PTGER1RXRARXRBRXRGPTGER4 | |
| SCHEMBL9526423 | 0.77 | PTGER1 (0.72) | PTGER1RXRARXRBRXRGMRGPRX4 | |
| Acetic Acid SCHEMBL5690407 | 0.77 | RXRA (0.72) | PTGER1RXRARXRBRXRGPTGER4 | |
| SCHEMBL10466517 | 0.77 | MAOB (0.69) | MEN1KMT2A | |
| SCHEMBL9707413 | 0.75 | MRGPRX4 (0.70) | MRGPRX4SMN1; SMN2NPC1RAB9AMAPT | |
| SCHEMBL1667780 | 0.74 | PTGER1 (0.72) | PTGER1RXRARXRBRXRGPTGER4 | |
| SCHEMBL201074 | 0.73 | RXRA (0.70) | PTGER1RXRARXRBRXRGPTGER4 | |
| SCHEMBL5096132 | 0.72 | PTGER1 (1.00) | PTGER1RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL9508299 | 0.72 | ALOX5 (0.58) | L3MBTL1NPC1RAB9AMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| US-4738986-A | CYCLOOXYGENASE, LIDOXYGENASE INHIBITORS | BURROUGHS WELLCOME CO. (US) | 1988-04-19 | — | — | US | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |