Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | GFER | P55789 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 1/20 | 0.34 |
| ▸ | COMT | P21964 | 1/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10933135 | 0.75 | ALDH1A1 (0.55) | GAAKDM4EPOLBALDH1A1MEN1 | |
| SCHEMBL6763593 | 0.74 | ADRA1B (0.49) | GAAKDM4EPOLBALDH1A1MEN1 | |
| SCHEMBL3984909 | 0.72 | ADRA1B (0.45) | GAAKDM4EPOLBALDH1A1MEN1 | |
| SCHEMBL9877542 | 0.72 | KMT2A (0.42) | KDM4EPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL29842516 | 0.70 | F10 (0.43) | GAAKDM4EPOLBMEN1KMT2A | |
| SCHEMBL25001894 | 0.69 | GAA (0.38) | GAAKDM4EPOLBALDH1A1MEN1 | |
| SCHEMBL6769390 | 0.67 | SCN9A (0.46) | GAAKDM4EPOLBALDH1A1MEN1 | |
| SCHEMBL21770162 | 0.66 | VHL (0.37) | POLBALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL22411022 | 0.66 | MEN1 (0.44) | GAAPOLBALDH1A1MEN1KMT2A | |
| SCHEMBL14899249 | 0.66 | GAA (0.42) | GAAKDM4EPOLBMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5036157-A | Hydroxamic acid derivatives, lipoxygenase and cyclooxygenase inhibitors, anticoagulants, antiinflammatory agents | BURROUGHS WELLCOME CO. | 1991-07-30 | — | — | US | disclosed |
| US-4977188-A | Hydroamic acid derivatives | BURROUGHS WELLCOME CO. (US) | 1990-12-11 | — | — | US | disclosed |
| WO-1990001929-A1 | NEW MEDICAL USE | THE WELLCOME FOUNDATION LIMITED (GB) | 1990-03-08 | — | — | WO | disclosed |
| EP-0196184-A2 | Aryl derivatives | THE WELLCOME FOUNDATION LIMITED (GB) | 1986-10-01 | — | — | EP | disclosed |