Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | HPGD | P15428 | 3/20 | 0.48 |
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.48 |
| ▸ | RELA | Q04206 | 2/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | STAT1 | P42224 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | GPR119 | Q8TDV5 | 8/20 | 0.44 |
| ▸ | PTGIR | P43119 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9877095 | 0.75 | SMN1; SMN2 (0.76) | SMN1; SMN2ALDH1A1HPGDTSHRNPC1 | |
| SCHEMBL25380972 | 0.75 | FGFR3 (0.47) | SMN1; SMN2ALDH1A1HPGDTSHRNPC1 | |
| SCHEMBL8947161 | 0.75 | TP53 (0.46) | SMN1; SMN2ALDH1A1TSHRNPC1MAPT | |
| SCHEMBL9877332 | 0.74 | MAPT (0.54) | SMN1; SMN2ALDH1A1HPGDTSHRNPC1 | |
| SCHEMBL16985359 | 0.73 | CYP4F2 (0.39) | SMN1; SMN2ALDH1A1HPGDTSHRNPC1 | |
| SCHEMBL20028106 | 0.72 | ALDH1A1 (0.65) | SMN1; SMN2ALDH1A1HPGDTSHRNPC1 | |
| SCHEMBL21850227 | 0.71 | ALDH1A1 (0.39) | SMN1; SMN2ALDH1A1HPGDTSHRNPC1 | |
| SCHEMBL9877279 | 0.70 | SMN1; SMN2 (0.68) | SMN1; SMN2ALDH1A1HPGDTSHRNPC1 | |
| SCHEMBL2394924 | 0.70 | POLB (0.46) | SMN1; SMN2ALDH1A1HPGDTSHRNPC1 | |
| SCHEMBL9878548 | 0.69 | SMN1; SMN2 (0.67) | SMN1; SMN2ALDH1A1HPGDTSHRNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4988725-A | Cardiovascular disorders, antiarrhythmia agents | STERLING DRUG INC. (US) | 1991-01-29 | — | — | US | disclosed |
| EP-0388654-A2 | Azole-1-alkanamides as antiarrhythmic agents and preparation thereof | STERLING DRUG INC. (US) | 1990-09-26 | — | — | EP | disclosed |
| US-4916150-A | 1H-pyrazole-1-alkanamines antiarrhythmic compositions and use | STERLING DRUG INC. (US) | 1990-04-10 | — | — | US | disclosed |